The goal of the Protocol Review and Monitoring System (PRMS) is to ensure the highest scientific quality and patient safety for individuals going on clinical cancer studies at UTSW. The Simmons Cancer Center PRMC consists of the Protocol Review and Monitoring Committee (PRMC), the Data and Safety Monitoring Committee (DSMC), and the administrafive support services of the Clinical Research Office Shared Resource (CRO). These three entifies are overseen by the Clinical Cancer Research Committee (CCRC), which aids the Deputy Director in overseeing all clinical research activities conducted at the Cancer Center, recommends new policies and procedures to the Deputy Director, and identifies scienfific priorities and clinical issues in the cancer center. The CCRC is chaired by the Deputy Director, and co-chaired by the Associate Director for Clinical Research. The PRMC reviews and monitors all cancer-related clinical studies for scientific merit. In addition, it is responsible for overseeing the scientific progress of open clinical trials by monitoring accrual to all SCCC protocols. The PRMC is chaired by Dr. Hak Choy, Professor and Chair of Radiafion Oncology, and co-chaired by Dr. Chul Ahn, Professor of Biostafisfics. Members are appointed by the Cancer Center Deputy Director and represent the expertise necessary to provide high-level clinical oncology protocol reviews and monitoring of those which receive committee approval. All UTSW clinical trials involving cancer pafients must receive PRMC approval before the IRB will schedule it for review. The DSMC is designed to ensure pafient safety and data quality for cancer-related clinical trials. The DSMC is an independent committee appointed by the Deputy Director of the Cancer Center and chaired by Dr. David Euhus, Associate Director for Clinical Research, and is responsible for carrying out the data and safety monitoring plan for the Cancer Center. The CRO is headed by Ms. Lynn Baker, Assistant Director for Clinical Research, and is responsible for inifiafing, implemenfing, and conducfing clinical research protocols in the Cancer Center. The CRO staff includes clinical research coordinafing personnel, as well as staff that provide regulatory and operafional support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA142543-03
Application #
8380784
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$20,482
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Pruitt, Sandi L; Werner, Claudia L; Borton, Eric K et al. (2018) Cervical Cancer Burden and Opportunities for Prevention in a Safety-Net Healthcare System. Cancer Epidemiol Biomarkers Prev 27:1398-1406
Shay, Laura A; Baldwin, Austin S; Betts, Andrea C et al. (2018) Parent-Provider Communication of HPV Vaccine Hesitancy. Pediatrics 141:
Murphy, Caitlin C; Sigel, Bianca M; Yang, Edward et al. (2018) Adherence to colorectal cancer screening measured as the proportion of time covered. Gastrointest Endosc 88:323-331.e2
Taylor 4th, Clinton A; An, Sung-Wan; Kankanamalage, Sachith Gallolu et al. (2018) OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant. Proc Natl Acad Sci U S A 115:3840-3845
Deng, Mi; Gui, Xun; Kim, Jaehyup et al. (2018) LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature 562:605-609
Lee, Simon Craddock; Higashi, Robin T; Sanders, Joanne M et al. (2018) Effects of program scale-up on time to resolution for patients with abnormal screening mammography results. Cancer Causes Control 29:995-1005
Singal, Amit G; Tiro, Jasmin A; Murphy, Caitlin C et al. (2018) Mailed Outreach Invitations Significantly Improve HCC Surveillance Rates in Patients With Cirrhosis: A Randomized Clinical Trial. Hepatology :
Ludlow, Andrew T; Wong, Mandy Sze; Robin, Jerome D et al. (2018) NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nat Commun 9:3112
Lewis, Joshua E; Costantini, Francesco; Mims, Jade et al. (2018) Genome-Scale Modeling of NADPH-Driven ?-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma. Antioxid Redox Signal 29:937-952
Rinkenberger, Nicholas; Schoggins, John W (2018) Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses. MBio 9:

Showing the most recent 10 out of 501 publications