The Biospecimen and Tissue Procurement Shared Resource Facility (BSTP SRF) procures and distributes biospecimens and provides expertise and support to the University of Kentucky (IJK) Markey Cancer Center (MCC) researchers to perform specialized histopathologic, immunohistochemical and molecular analyses. The use of both neoplastic and non-neoplastic human and animal tissues is a key component of translational, population-based and basic science cancer research. The goals of the facility are to provide formalin-fixed paraffin-embedded (FFPE) tissues, frozen tissue, blood, and other specimens, and histopathological and immunohistochemistry expertise for the studies related to the aims of Markey Cancer Center (MCC)-supported research projects. To meet these goals, the following Specific Aims are proposed: 1) to provide quality-controlled human tissue biospecimens necessary for all research studies, including both frozen and FFPE tissues, annotated with clinical follow-up and outcomes;2) to provide expert pathological review for all clinical specimens utilized in the projects and to provide specific histopathological technical services as necessary for analysis of all clinical and animal tissues;and 3) to coordinate and facilitate acquisition and quality control of tissue samples from the MCC affiliate hospitals required for the studies. The BSTP SRF will leverage the existing resources within the MCC, the UK Department of Pathology and Laboratory Medicine, the MCC Clinical Research and Data Management Shared Resource Facility and the Kentucky Cancer Registry, thus assuring that this core benefits from previous efforts and techniques and that funds are used efficiently without reproducing existing facilities.
A central biospecimen repository, processing, and analysis facility specifically for cancer, provides for productive and efficient use of resources to achieve the specific aims of cancer research projects in a timely fashion. A particularly novel aspect of our facility is the large sample repository (tissue, blood, urine, toenails) from individuals in Appalachia, an underserved population with a disproportionate incidence of lung and colorectal cancer. This repository has facilitated population-based studies in this region.
|Hubbard, W Brad; Harwood, Christopher L; Geisler, John G et al. (2018) Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice. J Neurosci Res 96:1677-1688|
|Alghamedy, Fatemah; Bopaiah, Jeevith; Jones, Derek et al. (2018) Incorporating Protein Dynamics Through Ensemble Docking in Machine Learning Models to Predict Drug Binding. AMIA Jt Summits Transl Sci Proc 2017:26-34|
|Wen, Yang-An; Xiong, Xiaopeng; Zaytseva, Yekaterina Y et al. (2018) Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer. Cell Death Dis 9:265|
|Zhang, Hui; Fredericks, Tricia; Xiong, Gaofeng et al. (2018) Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance. Breast Cancer Res 20:116|
|Zhong, Weixiong; Weiss, Heidi L; Jayswal, Rani D et al. (2018) Extracellular redox state shift: A novel approach to target prostate cancer invasion. Free Radic Biol Med 117:99-109|
|Liu, Xinan; Yu, Ye; Liu, Jinpeng et al. (2018) A novel data structure to support ultra-fast taxonomic classification of metagenomic sequences with k-mer signatures. Bioinformatics 34:171-178|
|Xiong, Gaofeng; Stewart, Rachel L; Chen, Jie et al. (2018) Collagen prolyl 4-hydroxylase 1 is essential for HIF-1? stabilization and TNBC chemoresistance. Nat Commun 9:4456|
|Jarrett, Stuart G; Carter, Katharine M; Bautista, Robert-Marlo et al. (2018) Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage. J Biol Chem 293:19025-19037|
|Al-Darraji, Ahmed; Haydar, Dalia; Chelvarajan, Lakshman et al. (2018) Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. PLoS One 13:e0200474|
|Choi, Yohan; Rosewell, Katherine L; Brännström, Mats et al. (2018) FOS, a Critical Downstream Mediator of PGR and EGF Signaling Necessary for Ovulatory Prostaglandins in the Human Ovary. J Clin Endocrinol Metab 103:4241-4252|
Showing the most recent 10 out of 359 publications