Innovation and progress in cancer research require dedication to the career development of the next generation of cancer researchers. Accordingly, the University of Kentucky?s Markey Cancer Center (MCC), with a robust annual institutional investment of $450,000 and the dedication of its members, established a comprehensive Oncology Career Enhancement Program. Over the past funding cycle, this program has provided enriching experiences for nearly 570 K-12 and undergraduate students; extensive research training for 50 high school students, 223 undergraduates and 544 graduate/postdoctoral researchers; and mentorship to 46 junior faculty. Notably, key education activities address the academic challenges of rural Appalachian Kentucky and underrepresented minorities through the support from 4 grants that include Continuing Umbrella of Research Experiences and Geographic Management of Health Disparities Program National Cancer Institute supplements. Academic and professional development of all trainees through intensive mentored research engagement and/or formal research training at the undergraduate, graduate and postdoctoral levels complement elementary and high school education strategies. Formal curricula in cancer biology have been established at the undergraduate, masters and pre-doctoral levels that provide the academic context for this training. Furthermore, 4 T32 training programs support cancer career development for trainees, including 2 funded by the National Cancer Institute, 1 of which is uniquely devoted to surgeon-scientists. Overall MCC training and career development extramural support has risen by 52% since 2012 to 26 grants totaling $2.3M (direct costs) in 2017. Early-career faculty benefit from team-based mentoring through formal mentoring committees, a Grant Writing Study Hall, the Clinical Trials Boot Camp and synergistic mentorship through various institutional efforts. This mentorship has resulted in 95 awarded grants (50 extramural, 45 intramural) and the development of 11 clinician scientists who went on to lead 31 clinical trials. A rich set of seminar, symposia, meetings and other career enhancement activities facilitate successful career development for all individuals engaged in cancer research and clinical practice. All current and proposed career enhancement activities leverage the robust research strengths within the MCC?s 4 Research Programs to provide immersive training across the pipeline and to ensure that faculty within these programs successfully develop as independent scientists. The MCC?s collective efforts also draw on strong institutional training resources to achieve 2 overarching goals of this program: to guide cohesive growth and coordinate transdisciplinary education and mentoring endeavors across the MCC; and to integrate with other efforts campus wide. Through CCSG support, this comprehensive program will continue to evolve innovative curricula and strategically linked initiatives that prepare trainees and early-career faculty for modern cancer career opportunities. Furthermore, these efforts will drive research innovation that will improve the lives of all Kentuckians.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
United States
Zip Code
Chauhan, Aman; Farooqui, Zainab; Murray, Le Aundra et al. (2018) Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary. J Oncol 2018:3519247
Zhang, Xiaofei; Zhang, Yi; Han, Erik Y et al. (2018) Classification of Whole Mammogram and Tomosynthesis Images Using Deep Convolutional Neural Networks. IEEE Trans Nanobioscience 17:237-242
Li, Jing; Song, Jun; Li, Xian et al. (2018) FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice. Endocrinology 159:2939-2952
Rodriguez, Sharon D; Vanderford, Nathan L; Huang, Bin et al. (2018) A Social-Ecological Review of Cancer Disparities in Kentucky. South Med J 111:213-219
Chauhan, Aman; Yu, Qian; Ray, Neha et al. (2018) Global burden of neuroendocrine tumors and changing incidence in Kentucky. Oncotarget 9:19245-19254
Huang, Bin; Pollock, Elizabeth; Zhu, Li et al. (2018) Ranking composite Cancer Burden Indices for geographic regions: point and interval estimates. Cancer Causes Control 29:279-287
Rea, Matthew; Gripshover, Tyler; Fondufe-Mittendorf, Yvonne (2018) Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells. Toxicol Appl Pharmacol 338:124-133
Yarana, Chontida; Carroll, Dustin; Chen, Jing et al. (2018) Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury. Clin Cancer Res 24:1644-1653
Banerjee, Moumita; Cui, Xiaoyu; Li, Zhichuan et al. (2018) Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth. Sci Rep 8:12322
Ji, Xuemei; Bossé, Yohan; Landi, Maria Teresa et al. (2018) Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat Commun 9:3221

Showing the most recent 10 out of 359 publications