? BIOSTATISTICS SHARED RESOURCE Shared Resource Leader: Madhu Mazumdar, PhD The Tisch Cancer Institute (TCI) Biostatistics Shared Resource Facility (BSRF) members participate actively in the design of new studies in basic science, clinical, epidemiological, survey, and cancer prevention. Early involvement of the BSRF members in the research teams enables the optimal design and analysis of pilot studies, adequate assessment of measurement properties of outcomes, assistance with appropriate database development, and meta-analysis of published literature, as needed for effective planning of new research. BSRF also fosters standardized review of protocols and monitoring of safety data. Members of the BSRF engage with faculty and staff in Information Technology to develop databases using Mount Sinai's electronic Research Application Portal (eRAP), perform analysis of small and `big' data (?omics? and high-dimensional data) in their collaboration with TCI investigators, and participate in graduate education programs developed for trainees and junior faculty in cancer research. In addition to providing training on analytic aspects of projects during collaborative consult sessions, BSRF members organize an Open House (for getting to know the biostatisticians in an informal setting), BioStat Clinic (sessions where consults are provided on a walk-in basis and often some training slides are presented on topics advertised a priori) and Journal Club (where methodology used in recent publications are discussed for potential application on local projects). All collaborative, review, and training work are provided free of charge with a strong requirement for biostatisticians to be included for significant FTE on all grants and contracts as a co-investigator. Biostatisticians are also required to be co-authors if ICJME criteria are met.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Shafik, Hasnaa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
New York
United States
Zip Code
Zhang, Yan M; Zimmer, Milena A; Guardia, Talia et al. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Dev Cell 45:580-594.e7
Parua, Pabitra K; Booth, Gregory T; Sansó, Miriam et al. (2018) A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. Nature 558:460-464
Lee, Youngmin A; Noon, Luke A; Akat, Kemal M et al. (2018) Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap. Nat Commun 9:4962
Schwartz, Rebecca M; Gorbenko, Ksenia; Kerath, Samantha M et al. (2018) Thoracic surgeon and patient focus groups on decision-making in early-stage lung cancer surgery. Future Oncol 14:151-163
Scarborough, Bethann M; Smith, Cardinale B (2018) Optimal pain management for patients with cancer in the modern era. CA Cancer J Clin 68:182-196
Laganà, A; Perumal, D; Melnekoff, D et al. (2018) Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Leukemia 32:120-130
D'Avola, Delia; Villacorta-Martin, Carlos; Martins-Filho, Sebastiao N et al. (2018) High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma. Sci Rep 8:11570
Chiang, David; Chen, Xintong; Jones, Stacie M et al. (2018) Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets. J Allergy Clin Immunol 141:2107-2120
Abbate, Franco; Badal, Brateil; Mendelson, Karen et al. (2018) FBXW7 regulates a mitochondrial transcription program by modulating MITF. Pigment Cell Melanoma Res :
Serasinghe, Madhavika N; Gelles, Jesse D; Li, Kent et al. (2018) Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition. Cell Death Dis 9:29

Showing the most recent 10 out of 143 publications