Abstract

The Protocol Review and Monitoring System (PRMS) of the Tisch Cancer Institute (TCI) oversees all cancer related clinical research conducted at the Mount Sinai Health System (MSHS). The major goal of the PRMS is to assure adequate internal oversight of the scientific aspects of cancer-related research by providing a rigorous initial scientific review and performing ongoing monitoring for scientific progress and accrual onto active cancer protocols. Protocol review is comprised of three components: Biostatistics Design Workshop, Disease Focus Groups, and the Protocol Review and Monitoring Committee (PRMC). Only the PRMC has the authority to open protocols that meet the scientific merit and priorities of the TCI and to terminate protocols that do not demonstrate scientific progress.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA196521-06
Application #
10022670
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
2015-08-01
Project End
2025-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Scarborough, Bethann M; Smith, Cardinale B (2018) Optimal pain management for patients with cancer in the modern era. CA Cancer J Clin 68:182-196
Laganà, A; Perumal, D; Melnekoff, D et al. (2018) Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Leukemia 32:120-130
D'Avola, Delia; Villacorta-Martin, Carlos; Martins-Filho, Sebastiao N et al. (2018) High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma. Sci Rep 8:11570
Chiang, David; Chen, Xintong; Jones, Stacie M et al. (2018) Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets. J Allergy Clin Immunol 141:2107-2120
Abbate, Franco; Badal, Brateil; Mendelson, Karen et al. (2018) FBXW7 regulates a mitochondrial transcription program by modulating MITF. Pigment Cell Melanoma Res :
Serasinghe, Madhavika N; Gelles, Jesse D; Li, Kent et al. (2018) Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition. Cell Death Dis 9:29
Sonoshita, Masahiro; Scopton, Alex P; Ung, Peter M U et al. (2018) A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol 14:291-298
Linde, Nina; Casanova-Acebes, Maria; Sosa, Maria Soledad et al. (2018) Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun 9:21
Rattay, T; Symonds, R P; Shokuhi, S et al. (2018) The Patient Perspective on Radiogenomics Testing for Breast Radiation Toxicity. Clin Oncol (R Coll Radiol) 30:151-157
Hirschfield, Hadassa; Bian, C Billie; Higashi, Takaaki et al. (2018) In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment. Exp Mol Med 50:e419

Showing the most recent 10 out of 143 publications