Abstract

The Protocol Review and Monitoring System (PRMS) of the Tisch Cancer Institute (TCI) oversees all cancer related clinical research conducted at the Mount Sinai Health System (MSHS). The major goal of the PRMS is to assure adequate internal oversight of the scientific aspects of cancer-related research by providing a rigorous initial scientific review and performing ongoing monitoring for scientific progress and accrual onto active cancer protocols. Protocol review is comprised of three components: Biostatistics Design Workshop, Disease Focus Groups, and the Protocol Review and Monitoring Committee (PRMC). Only the PRMC has the authority to open protocols that meet the scientific merit and priorities of the TCI and to terminate protocols that do not demonstrate scientific progress.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA196521-06
Application #
10022670
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
2015-08-01
Project End
2025-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Galsky, Matthew D; Wang, Huan; Hahn, Noah M et al. (2018) Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes. Eur Urol 73:751-759
Tsuchida, Takuma; Lee, Youngmin A; Fujiwara, Naoto et al. (2018) A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. J Hepatol 69:385-395
Molotkov, Andrei; Soriano, Philippe (2018) Distinct mechanisms for PDGF and FGF signaling in primitive endoderm development. Dev Biol 442:155-161
Wu, Vernon; Moshier, Erin; Leng, Siyang et al. (2018) Risk stratification of smoldering multiple myeloma: predictive value of free light chains and group-based trajectory modeling. Blood Adv 2:1470-1479
Parua, Pabitra K; Booth, Gregory T; Sansó, Miriam et al. (2018) A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. Nature 558:460-464
Zhang, Yan M; Zimmer, Milena A; Guardia, Talia et al. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Dev Cell 45:580-594.e7
Schwartz, Rebecca M; Gorbenko, Ksenia; Kerath, Samantha M et al. (2018) Thoracic surgeon and patient focus groups on decision-making in early-stage lung cancer surgery. Future Oncol 14:151-163
Lee, Youngmin A; Noon, Luke A; Akat, Kemal M et al. (2018) Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap. Nat Commun 9:4962
Laganà, A; Perumal, D; Melnekoff, D et al. (2018) Integrative network analysis identifies novel drivers of pathogenesis and progression in newly diagnosed multiple myeloma. Leukemia 32:120-130
Scarborough, Bethann M; Smith, Cardinale B (2018) Optimal pain management for patients with cancer in the modern era. CA Cancer J Clin 68:182-196

Showing the most recent 10 out of 143 publications