This is a proposal to renew funding of the Center for Drug Use and HIV Research (CDUHR) for years 21- 25. Recent advances in HIV biomedical and behavioral science have been shown to reduce HIV incidence and allow HIV-positive persons to reach near-normal lifespans. These achievements have led UNAIDS, the US and several local governments to propose strategies for ?Ending the HIV Epidemic?. Notwithstanding these successes, attaining this goal among people who use drugs (PWUD) will require addressing a number of important existing barriers. The overall theme of this renewal is ?Ending HIV/AIDS among People who use Drugs: Overcoming Challenges?. We define Ending HIV/AIDS as reducing new infections and increasing the proportion of PWUD who are virally suppressed. To accomplish this, we have identified these research priorities, which directly address the most significant challenges: (1) Devise new strategies to overcome emerging and persistent barriers to ending HIV/AIDS among PWUD. Barriers include recent increases in prescription opioid misuse, which have given rise to a new generation of heroin user and injectors, and lack of attention to the key role of substance use in new infections in men who have sex with men and heterosexuals. HIV-positive PWUD also experience disparities all along the continuum of HIV care, including delayed diagnosis, lower retention in care, delayed initiation of ART and poorer disease outcomes. (2) Conduct research on effective ways to broadly implement evidence-based interventions. HIV prevention and care programs for PWUD do not exist in many regions of the US and the rest of the world where they are needed most, and they are rarely implemented at public-health scale. (3) Develop new, innovative models of prevention and treatment interventions to address substance-use related disparities in HIV infection and treatment outcomes that take into account the complex, multilevel nature of HIV among PWUD. We have made significant changes in our scope and structure for this renewal, and we will achieve our aims through five Cores, an Administrative Core and four Research Support Cores: (1) Infectious Disease Epidemiology and Theory, (2) Transdisciplinary Research Methods, (3) Dissemination and Implementation, and (4) Pilot Projects and


These Cores support our research base and affiliated investigators to conduct cutting-edge science and enhance synergy across investigators from multiple disciplines, thereby leading to contributions to the field that are beyond what the individual projects could have achieved. In addition to the many successful initiatives that have been developed over CDUHR's history, new activities were added to respond to the evolving needs of our investigators. Also, in addition to our ongoing commitment to train new investigators to conduct high-impact research, we will collaborate with investigators in areas where HIV epidemics are occurring among PWUD (in rural and middle America, and in eastern Europe and Asia), building on our collective knowledge and expertise to advance toward Ending HIV/AIDS in those regions.

Public Health Relevance

A critical time has been reached in the course of the HIV epidemic, when the possibility to end HIVAIDS has been raised. Despite advances in biomedical treatments and behavioral interventions to reduce HIV incidence and its impact, people who use drugs (PWUD) have poorer outcomes. The Center provides a research infrastructure to enhance the productivity, synergy and impact of the research by affiliated investigators working to End HIV/AIDS among PWUD.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Lloyd, Jacqueline
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
Schools of Nursing
New York
United States
Zip Code
McNeely, Jennifer; Haley, Sean J; Smith, Allison J et al. (2018) Computer self-administered screening for substance use in university student health centers. J Am Coll Health :1-10
Platt, Lucy; Minozzi, Silvia; Reed, Jennifer et al. (2018) Needle and syringe programmes and opioid substitution therapy for preventing HCV transmission among people who inject drugs: findings from a Cochrane Review and meta-analysis. Addiction 113:545-563
Simmons, Janie; Rajan, Sonali; Goldsamt, Lloyd A et al. (2018) Implementation of Online Opioid Prevention, Recognition and Response Trainings for Laypeople: Year 1 Survey Results. Subst Use Misuse 53:1997-2002
Nowlin, Sarah; Cleland, Charles M; Parekh, Niyati et al. (2018) Racial and ethnic disparities in predictors of glycemia: a moderated mediation analysis of inflammation-related predictors of diabetes in the NHANES 2007-2010. Nutr Diabetes 8:56
Palamar, Joseph J; Le, Austin; Mateu-Gelabert, Pedro (2018) Not just heroin: Extensive polysubstance use among US high school seniors who currently use heroin. Drug Alcohol Depend 188:377-384
Barnes, David M; Des Jarlais, Don C; Wolff, Margaret et al. (2018) A qualitative study of persons who inject drugs but who have never helped others with first injections: how their views on helping contrast with the views of persons who have helped with first injections, and implications for interventions. Harm Reduct J 15:43
Umbach, Rebecca; Raine, Adrian; Leonard, Noelle R (2018) Cognitive Decline as a Result of Incarceration and the Effects of a CBT/MT Intervention: A Cluster-Randomized Controlled Trial. Crim Justice Behav 45:31-55
Tempalski, Barbara; Cooper, Hannah L F; Kelley, Mary E et al. (2018) Identifying Which Place Characteristics are Associated with the Odds of Recent HIV Testing in a Large Sample of People Who Inject Drugs in 19 US Metropolitan Areas. AIDS Behav :
Gwadz, Marya; Leonard, Noelle R; Honig, Sylvie et al. (2018) Doing battle with ""the monster:"" how high-risk heterosexuals experience and successfully manage HIV stigma as a barrier to HIV testing. Int J Equity Health 17:46
Mateu-Gelabert, Pedro; Guarino, H; Quinn, K et al. (2018) Young Drug Users: a Vulnerable Population and an Underutilized Resource in HIV/HCV Prevention. Curr HIV/AIDS Rep :

Showing the most recent 10 out of 339 publications