Abstract

The four institutions that comprise the Woodruff Health Sciences Center of Emory University- The School of Medicine, the Rollins School of Public Health, the Hell Hodgson Woodruff School of Nursing, and the Yerkes regional Primate Research Center; the four major affiliated health care institutions of the Woodruff Health Sciences University, and the Atlanta Veterans Affairs Medical Center-as well as the CPCRA site in Atlanta-The AIDS Research Consortium of Atlanta-present this application for a Center for AIDS Research (CFAR) being fully committed to a multidisciplinary and interdisciplinary approach to HIV/AIDS research. The proposed Emory/Atlanta CFAR, in a effort to provide a focus for activities, has chosen to emphasize as a theme HIV/AIDS prevention science through basic, clinical and behavioral research. The development of excellent multidisciplinary research approaches to HIV/AIDS in Atlanta, the spirit of and need for collaboration, and the extensive epidemic of HIV/AIDS in the region have led to this application. The primary goal of the proposed Atlanta/Emory Center for AIDS Research is to link and enhance collaborations among Emory University-sponsored research programs and between Emory and the other major AIDS research efforts in Atlanta. Specific goals are: 1. To develop an administrative structure that links and strengthens Emory/Atlanta/Georgia AIDS research programs. 2. To foster collaborative research for the prevention of HIV transmission in Atlanta and the region. Interdisciplinary research in groups (e.g. women, minorities) which represent the rapidly changing epidemic of AIDS in the region can be expanded with CFAR encouragement and resources. 3. To provide a mechanism of stimulating interdisciplinary collaborations between basic, clinical, and behavioral HIV/AIDS researchers of Atlanta. 4. To enhance progress in HIV/AIDS research through provision of integrated core facilities. 5. To stimulate the development of young investigators in HIV/AIDS research. 6. To encourage investigators who are not currently working in AIDS to pursue HIV/AIDS research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
3P30DA012121-03S1
Application #
6504831
Study Section
Special Emphasis Panel (ZAI1 (J1))
Program Officer
Reichelderfer, Patricia
Project Start
1998-08-01
Project End
2002-09-22
Budget Start
2000-08-01
Budget End
2002-09-22
Support Year
3
Fiscal Year
2001
Total Cost
$729,250
Indirect Cost

  Institution

Name
Emory University
Department
Type
Schools of Public Health
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Hulgan, Todd; Stein, James H; Cotter, Bruno R et al. (2013) Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res Hum Retroviruses 29:1293-9
Huang, Jeannie S; Hughes, Michael D; Riddler, Sharon A et al. (2013) Bone mineral density effects of randomized regimen and nucleoside reverse transcriptase inhibitor selection from ACTG A5142. HIV Clin Trials 14:224-34
Haubrich, Richard H; Riddler, Sharon A; Ribaudo, Heather et al. (2011) Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and nucleoside reverse transcriptase inhibitor-sparing regimens for first-line therapy of HIV infection AIDS 25:2269-78
Hulgan, Todd; Haubrich, Richard; Riddler, Sharon A et al. (2011) European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. AIDS 25:37-47
Thomas, Ajit G; Bodner, Amos; Ghadge, Ghanashyam et al. (2009) GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. J Neurovirol 15:449-57
Haubrich, Richard H; Riddler, Sharon A; DiRienzo, A Gregory et al. (2009) Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS 23:1109-18
Pillai, Vinod Bhaskara; Hellerstein, Michael; Yu, Tianwei et al. (2008) Comparative studies on in vitro expression and in vivo immunogenicity of supercoiled and open circular forms of plasmid DNA vaccines. Vaccine 26:1136-41
Riddler, Sharon A; Haubrich, Richard; DiRienzo, A Gregory et al. (2008) Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med 358:2095-106
Sadagopal, Shanmugalakshmi; Amara, Rama Rao; Kannanganat, Sunil et al. (2008) Expansion and exhaustion of T-cell responses during mutational escape from long-term viral control in two DNA/modified vaccinia virus Ankara-vaccinated and simian-human immunodeficiency virus SHIV-89.6P-challenged macaques. J Virol 82:4149-53
Lai, Lilin; Vodros, Dalma; Kozlowski, Pamela A et al. (2007) GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology 369:153-67

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