Abstract

The Cell and Immunology Core will to continue to offer assays to extend the work of laboratories at Temple University and of outside collaborators who want to add immune or histological/pathological end-points to their studies. Dr. Eisenstein will supervise the work to be carried out in Aims 1, 2, and 4. A major addition to the Core in this renewal is Dr. Yuri Persidsky. Trained as a pathologist, he will supervise new services offered by the Cell and Immunology Core as related to analysis of tissue as described in Aim 3. In addition, he will bring his expertise in HIV-1 infection of relevant human cells and the blood-brain barrier (BBB) to the Core, as well as projects using the HIV-1-infected humanized NOD.Cg-Prkdcscid ll2rgtm1Wjl /SzJ (NSG mice or huNSG) mouse model that recapitulates key features of infection in humans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
5P30DA013429-19
Application #
9460482
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
19
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Liu, Jeffrey J; Sharma, Kirti; Zangrandi, Luca et al. (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360:
Oliver, Chicora F; Simmons, Steven J; Nayak, Sunil U et al. (2018) Chemokines and 'bath salts': CXCR4 receptor antagonist reduces rewarding and locomotor-stimulant effects of the designer cathinone MDPV in rats. Drug Alcohol Depend 186:75-79
Zewde, Ashenafi Mebratu; Yu, Frances; Nayak, Sunil et al. (2018) PLDT (planarian light/dark test): an invertebrate assay to quantify defensive responding and study anxiety-like effects. J Neurosci Methods 293:284-288
Rom, Slava; Zuluaga-Ramirez, Viviana; Reichenbach, Nancy L et al. (2018) Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation 15:25
Ramirez, Servio H; Andrews, Allison M; Paul, Debayon et al. (2018) Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers. Fluids Barriers CNS 15:19
Brailoiu, Eugen; Barlow, Christine L; Ramirez, Servio H et al. (2018) Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells. Neuroscience 377:105-113
Barbe, Mary F; Massicotte, Vicky S; Assari, Soroush et al. (2018) Prolonged high force high repetition pulling induces osteocyte apoptosis and trabecular bone loss in distal radius, while low force high repetition pulling induces bone anabolism. Bone 110:267-283
Gentile, Taylor A; Simmons, Steven J; Barker, David J et al. (2018) Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine. Addict Biol 23:247-255
Hicks, Callum; Huang, Peng; Ramos, Linnet et al. (2018) Dopamine D1-Like Receptor Agonist and D2-Like Receptor Antagonist (-)-Stepholidine Reduces Reinstatement of Drug-Seeking Behavior for 3,4-Methylenedioxypyrovalerone (MDPV) in Rats. ACS Chem Neurosci 9:1327-1337
Dziedowiec, Emily; Nayak, Sunil U; Gruver, Keenan S et al. (2018) Mu Opioid Receptor Agonist DAMGO Produces Place Conditioning, Abstinence-induced Withdrawal, and Naltrexone-Dependent Locomotor Activation in Planarians. Neuroscience 386:214-222

Showing the most recent 10 out of 343 publications