The overall aim of this Core Center of Excellence (CCOE) is to conduct research that will transform etiological models of drug abuse and sexual risk behavior and the prevention programs they inform in general and those for rural African American children, youth, and their families in particular. The need for this transformation is documented by inclusive reviews of drug abuse and sexual risk behavior prevention efforts that reveal mixed and inconsistent results. This inconsistent impact is a major concern that indicates a need for new approaches to etiologic models of drug abuse and sexual risk behavior, particularly greater articulation of the ways in which the interface among genetic, psychosocial, and developmental processes can be used to transform them. To reach this goal we have assembled a team of senior and early career investigators with a successful history of collaboration who have backgrounds in molecular and statistical genetics, genetic epidemiology, public health, human development, and prevention science. This network of investigators will access the Shared Resources Core, a unique combination of data sets, genetic laboratory and specimen repository resources, statistical and bioinformatic services, and data collection and program implementation teams. Data from seven core projects were collected from more than 6,000 African American individuals, approximately 5,000 (83%) of whom live in small towns and rural communities. These data include (a) longitudinal assessments of drug use and abuse and sexual risk behavior phenotypes;(b) genetic data;(c) developmentally appropriate assessments of self-regulatory processes;and (d) multilevel assessments of individual characteristics, social adaptation, parenting/family processes, and neighborhood/community contexts. The organizational and administrative structure of the CCOE will organize and prioritize CCOE scientists'research efforts, providing an integrated process for translating findings into transformations of etiologic models of drug abuse and sexual risk behavior that increase their predictive utility and the efficacy of the prevention progress they inform.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
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Special Emphasis Panel (ZDA1-EXL-T (02))
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Crump, Aria
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University of Georgia
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United States
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Lei, Man-Kit; Beach, Steven R H; Simons, Ronald L (2018) Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age. Dev Psychopathol 30:1797-1815
Zapolski, Tamika C B; Rowe, Alia T; Banks, Devin E et al. (2018) Perceived Discrimination and Substance Use among Adolescents: Examining the Moderating Effect of Distress Tolerance and Negative Urgency. Subst Use Misuse :1-10
Owens, Max M; Amlung, Michael T; Stojek, Monika et al. (2018) Negative urgency moderates reactivity to laboratory stress inductions. J Abnorm Psychol 127:385-393
Barton, Allen W; Yu, Tianyi; Brody, Gene H et al. (2018) Childhood poverty, catecholamines, and substance use among African American young adults: The protective effect of supportive parenting. Prev Med 112:1-5
Barton, Allen W; Beach, Steven R H; Wells, Ashley C et al. (2018) The Protecting Strong African American Families Program: a Randomized Controlled Trial with Rural African American Couples. Prev Sci 19:904-913
Gerraty, Raphael T; Davidow, Juliet Y; Foerde, Karin et al. (2018) Dynamic flexibility in striatal-cortical circuits supports reinforcement learning. J Neurosci :
Goings, Trenette Clark; Salas-Wright, Christopher P; Howard, Matthew O et al. (2018) Substance use among bi/multiracial youth in the United States: Profiles of psychosocial risk and protection. Am J Drug Alcohol Abuse 44:206-214
Zapolski, Tamika C B; Banks, Devin E; Lau, Katherine S L et al. (2018) Perceived Police Injustice, Moral Disengagement, and Aggression Among Juvenile Offenders: Utilizing the General Strain Theory Model. Child Psychiatry Hum Dev 49:290-297
Kogan, Steven M; Cho, Junhan; Beach, Steven R H et al. (2018) Oxytocin receptor gene methylation and substance use problems among young African American men. Drug Alcohol Depend 192:309-315
Holmes, Christopher J; Barton, Allen W; MacKillop, James et al. (2018) Parenting and Salience Network Connectivity Among African Americans: A Protective Pathway for Health-Risk Behaviors. Biol Psychiatry 84:365-371

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