The administrative core will provide the leadership to ensure that this center continually stimulates new, significant and innovative research while simultaneously providing new """"""""cutting edge approaches"""""""" to enhance the goals of the research projects funded to investigators at this and neighboring institutions. The director of this center will have the responsibility for all aspects of this center but will be provided with daily input from the internal advisory committee some of whom have been colleagues for decades, and frequently from the external advisory committee. In addition the individual core leaders will serve in an advisory capacity with the major goal to stimulate new innovative research available due to collaboration among the cores. This core will rely heavily on continual interaction and communication among all scholars and advisors as they have done for years. There has been a long history of collaboration among the drug abuse researchers at this and neighboring institutions and this experience will provide the essence for the leadership of this center. Should it be necessary the internal advisory committee for this center along with the dean of the School of Medicine will designate one of the core directors or another senior investigator in the drug abuse field to become the center director. The administrative support for this center will be provided by the secretarial and financial personnel as requested in this application but they will have the very large and experienced administrative staff of the Department of Pharmacology and Toxicology as needed. Further, the offices of the School of Medicine and The Vice President for Research have and will continue to provide support at their respective levels.
The administrative core of this center will maintain the responsibility to ensure that the research carried out will be of such that it will lead to improvement in prevention and treatment of substance abuse diseases. The cores of this center have been chosen in part due to their applicability for translational research which is the central element of new treatments for these diseases.
|Donvito, Giulia; Nass, Sara R; Wilkerson, Jenny L et al. (2018) The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology 43:52-79|
|Wolstenholme, Jennifer T; Bowers, M Scott; Pais, Alexander B et al. (2018) Dietary Omega-3 Fatty Acids Differentially Impact Acute Ethanol-Responsive Behaviors and Ethanol Consumption in DBA/2J Versus C57BL/6J Mice. Alcohol Clin Exp Res :|
|Hermes, Douglas J; Xu, Changqing; Poklis, Justin L et al. (2018) Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology 141:55-65|
|Mischel, Ryan A; Dewey, William L; Akbarali, Hamid I (2018) Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators. iScience 2:193-209|
|Shin, Myungsun; Snyder, Helena W; Donvito, Giulia et al. (2018) Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo. Mol Pharm 15:721-728|
|Gonek, Maciej; McLane, Virginia D; Stevens, David L et al. (2018) CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward. Brain Behav Immun 69:124-138|
|Curry, Zachary A; Wilkerson, Jenny L; Bagdas, Deniz et al. (2018) Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. J Pharmacol Exp Ther 366:169-183|
|Cooper, Ziva D; Poklis, Justin L; Liu, Fei (2018) Methodology for controlled administration of smoked synthetic cannabinoids JWH-018 and JWH-073. Neuropharmacology 134:92-100|
|Grim, T W; Morales, A J; Thomas, B F et al. (2017) Apparent CB1 Receptor Rimonabant Affinity Estimates: Combination with THC and Synthetic Cannabinoids in the Mouse In Vivo Triad Model. J Pharmacol Exp Ther 362:210-218|
|Wilkerson, Jenny L; Ghosh, Sudeshna; Mustafa, Mohammed et al. (2017) The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology 114:156-167|
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