The overall goal of the new Core C is to provide resources, expertise, and training for RMTSC investigators to characterize the chemosensory capabilities and responsiveness of their model rodents. These include phenotypic assessment of transgenic and knockout mice, as well as organisms with experimentally induced taste and olfactory deficits, including localized delivery of pharmacological agents. The need for an assessment core has arisen because the numbers of gene-targeted and transgenic mice produced and/or utilized by established and new RMTSC core investigators has increased dramatically since the last funding period. Further, several new lines are being developed that will be utilized by multiple RMTSC investigators. These model organisms will require functional validation, both electrophysiological and behavioral. Electrophysiology core services include assistance with chorda tympani and glossopharyngeal taste nerve recording, to assess taste function in anterior and posterior lingual fields, and EOG recording, to assess function of the olfactory epithelium and olfactory nerve conduction. Behavioral assessment facilities include training and expertise in the design and execution of behavioral testing for both taste and olfactory function. These services include assistance with design and analysis of brief access taste tests using the Davis Rig llckometer, long-term 2-bottle preference tests, and olfactory function using the olfactometer. In addition to providing services for established investigators. Core C will aid new investigators who do not have the equipment or expertise to perform these assessments on their own. Further, having central core facilities will enhance collaborations among RMTSC investigators, and bring new investigators into the chemosensory field. It is not the intention of this core to perform all these studies for the participating laboratories, but rather to facilitate the capabilities of the participating laboratories to gain the requisite expertise.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1-SRB-Q (68))
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University of Colorado Denver
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Romanov, Roman A; Lasher, Robert S; High, Brigit et al. (2018) Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex. Sci Signal 11:
Stratford, J M; Larson, E D; Yang, R et al. (2017) 5-HT3A -driven green fluorescent protein delineates gustatory fibers innervating sour-responsive taste cells: A labeled line for sour taste? J Comp Neurol 525:2358-2375
Li, Anan; Guthman, Ethan M; Doucette, Wilder T et al. (2017) Behavioral Status Influences the Dependence of Odorant-Induced Change in Firing on Prestimulus Firing Rate. J Neurosci 37:1835-1852
Castillo-Azofeifa, David; Losacco, Justin T; Salcedo, Ernesto et al. (2017) Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development 144:3054-3065
Chang, Weipang; Kanda, Hirosato; Ikeda, Ryo et al. (2017) Serotonergic transmission at Merkel discs: modulation by exogenously applied chemical messengers and involvement of Ih currents. J Neurochem 141:565-576
Finger, Thomas E; Bartel, Dianna L; Shultz, Nicole et al. (2017) 5HTR3A-driven GFP labels immature olfactory sensory neurons. J Comp Neurol 525:1743-1755
Gaillard, Dany; Bowles, Spencer G; Salcedo, Ernesto et al. (2017) ?-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice. PLoS Genet 13:e1006990
Stratford, Jennifer M; Thompson, John A; Finger, Thomas E (2017) Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice. J Comp Neurol 525:271-290
Chang, Weipang; Kanda, Hirosato; Ikeda, Ryo et al. (2016) Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals. Proc Natl Acad Sci U S A 113:E5491-500
von Holstein-Rathlou, Stephanie; BonDurant, Lucas D; Peltekian, Lila et al. (2016) FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell Metab 23:335-43

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