Core A. Clinical Assessment CoreThe Clinical Assessment Core recruits and provides comprehensive assessments of research participants,and coordinates their participation in affiliated research projects. Brain-damaged individuals may be quitedissimilar in their patterns of cognitive dysfunction. Thus research projects affiliated with the HGARC aredependent oh a comprehensive understanding of each participant's neurological, neuroimaging,neurobehavioral, neuropsychological, and language status. The Clinical Assessment Core examinationconsists of four major components: (1) a medical/neurological evaluation conducted by a behavioralneurologist, (2) a speech/language evaluation conducted by a speech-language pathologist, (3) aneuropsychological evaluation conducted by a neuropsychologist, and (4) neuroimaging performed by theradiology service of affiliated hospitals and interpreted by the Assesement Gore neuroimaging specialists. Inaddition to recruitment and testing of participants with left- or right-hemispheric brain damgage, the ClinicalAssessment Core also recruits and screens matched control subjects. Newly added to our ClinicalAssessment Core during the current grant cycle is the Extended Assessment Clinic, used to assess over .time a subject's response to cognitive-linguistic treatment techniques in an early, developmental stage. Thisnew program responds directly to NIH initiatives for translational research, and, as documented in thisproposal, has already succeeded in serving as an incubator for new bench-to-bedside research. The HaroldGoodglass Aphasia Research Center has been providing recruitment and clinical assessment services toBoston-area researchers since its founding in the 1960s and is internationally recognized for its expertise inthe assessment and treatment of people with communication impairments. Recruiting research participantsfor aphasia and aphasia related research is costly and labor-intensive. Researchers have come to rely onthe HGARC for its comprehensive, efficient, and cost-effective support.
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| Cahana-Amitay, Dalia; Albert, Martin L (2014) Brain and language: evidence for neural multifunctionality. Behav Neurol 2014:260381 |
| Martin, Paula I; Treglia, Ethan; Naeser, Margaret A et al. (2014) Language improvements after TMS plus modified CILT: Pilot, open-protocol study with two, chronic nonfluent aphasia cases. Restor Neurol Neurosci 32:483-505 |
| Cahana-Amitay, Dalia; Albert, Martin L; Ojo, Emmanuel A et al. (2013) Effects of hypertension and diabetes on sentence comprehension in aging. J Gerontol B Psychol Sci Soc Sci 68:513-21 |
| Bullock-Rest, Natasha; Cerny, Alissa; Sweeney, Carol et al. (2013) Neural systems underlying the influence of sound shape properties of the lexicon on spoken word production: do fMRI findings predict effects of lesions in aphasia? Brain Lang 126:159-68 |
| Williams, Victoria J; Leritz, Elizabeth C; Shepel, Juli et al. (2013) Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults. Hum Brain Mapp 34:1826-41 |
| Naeser, Margaret A; Martin, Paula I; Ho, Michael et al. (2012) Transcranial magnetic stimulation and aphasia rehabilitation. Arch Phys Med Rehabil 93:S26-34 |
| Cahana-Amitay, Dalia; Albert, Martin L; Pyun, Sung-Bom et al. (2011) Language as a Stressor in Aphasia. Aphasiology 25:593-614 |
| Naeser, Margaret A; Martin, Paula I; Theoret, Hugo et al. (2011) TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia. Brain Lang 119:206-13 |
| Naeser, Margaret A; Martin, Paula I; Lundgren, Kristine et al. (2010) Improved language in a chronic nonfluent aphasia patient after treatment with CPAP and TMS. Cogn Behav Neurol 23:29-38 |
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