Scientific advances at our Center depend on specialized, computer-controlled experimental facilities for auditory research that are powerful and flexible enough to allow the efficient implementation of new paradigms. A major role of the Engineering Core is to design and maintain such specialized dataacquisition systems (Aim 1). This complex task involves selecting commercial instruments that are compatible with each other, installing these instruments, writing special software allowing them to be flexibly controlled by users, maintaining them, and upgrading them. Core Engineers also design and build electronic, acoustic and mechanical devices that are not commercially available (e.g. acoustic systems) to meet the constantly evolving requirements of physiological experiments (Aim 2). By web publishing of technical accomplishments, Core Engineers will share selected examples of our software and hardware solutions with the greater scientific community (Aim 3). The function of the Engineering Core is to facilitate both current research projects and new initiatives by taking advantage of emerging and mature technologies. The Engineering Core makes it possible for individual investigators to use sophisticated (or complicated) techniques that they would otherwise not be able to develop or use. By providing shared experimental facilities, the Engineering Core also encourages collaborative projects among the investigators using these facilities, and makes these facilities available to other NIH-funded investigators, external to the Center, who share an interest in hearing and deafness. Finally, the Engineering Core makes the scientific research of the Center more efficient by providing a knowledge bank that enables experimenters to be aware of and use techniques developed by another experimenter. In short, the Engineering Core increases the quantity and quality of the Center's scientific output, allowing us to better attack new issues in hearing and deafness.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005209-09
Application #
8071121
Study Section
Special Emphasis Panel (ZDC1)
Project Start
2010-06-01
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
9
Fiscal Year
2010
Total Cost
$406,165
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114
Currall, Benjamin B; Chen, Ming; Sallari, Richard C et al. (2018) Loss of LDAH associated with prostate cancer and hearing loss. Hum Mol Genet 27:4194-4203
Gao, Xue; Tao, Yong; Lamas, Veronica et al. (2018) Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature 553:217-221
Francis, Nikolas A; Zhao, Wei; Guinan Jr, John J (2018) Auditory Attention Reduced Ear-Canal Noise in Humans by Reducing Subject Motion, Not by Medial Olivocochlear Efferent Inhibition: Implications for Measuring Otoacoustic Emissions During a Behavioral Task. Front Syst Neurosci 12:42
Hancock, Kenneth E; Chung, Yoojin; McKinney, Martin F et al. (2017) Temporal Envelope Coding by Inferior Colliculus Neurons with Cochlear Implant Stimulation. J Assoc Res Otolaryngol 18:771-788
Zuk, Nathaniel; Delgutte, Bertrand (2017) Neural coding of time-varying interaural time differences and time-varying amplitude in the inferior colliculus. J Neurophysiol 118:544-563
Berezina-Greene, Maria A; Guinan Jr, John J (2017) Electrically Evoked Medial Olivocochlear Efferent Effects on Stimulus Frequency Otoacoustic Emissions in Guinea Pigs. J Assoc Res Otolaryngol 18:153-163
Nam, Hui; Guinan Jr, John J (2017) Non-tip auditory-nerve responses that are suppressed by low-frequency bias tones originate from reticular lamina motion. Hear Res 358:1-9
Valero, M D; Burton, J A; Hauser, S N et al. (2017) Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta). Hear Res 353:213-223
Kao, W Katherine; Gagnon, Patricia M; Vogel, Joseph P et al. (2017) Surface charge modification decreases Pseudomonas aeruginosa adherence in vitro and bacterial persistence in an in vivo implant model. Laryngoscope 127:1655-1661
Suzuki, Jun; Hashimoto, Ken; Xiao, Ru et al. (2017) Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep 7:45524

Showing the most recent 10 out of 169 publications