The laboratories of the Core-Center are uniformly technologically sophisticated and automated. Further, the faculty are engaged in a broad range of approaches, from molecular biology to cellular neurophysiology to behavior and perception, and utilize a variety of animal subjects as well as humans and patients. These attributes form a common need for technical services across the Core-Center. The Research Services Core (RSC) provides four sets of key services. Each operates in complementary partnerships with other NIHsupported Centers and Programs, and with the Department of Neurobiology and Anatomy. This structure ensures the highest quality of services and facilities possible, while maximizing efficiency and economy. The Histology &Imaging Unit provides tissue preparation, image analysis and reconstruction technologies, An additional component is an Imaging Facility that includes digital and wet darkrooms that facilitate transforming research findings into figures and images for publication and teaching tools. All investigators in the Co re-Center that use animals have a need for histological services, and yet the need does not justify full-time commitments. A collective solution is ideal. The Electronic and Mechanical Shop provides essential services to all labs, given the common requirement for equipment repair and maintenance overtime, and modifications and construction of electronic and mechanical components and devices on a semi-regular basis. The Shop exploits modern automated design-build technologies routinely. New faculty have expanded cellular-molecular-genetic levels of inquiry within the CNCS, and these approaches entail the use of mouse and other rodent models, including mutant and genetically engineered populations. A new Animal Research Unit assists CNCS investigators using rodents with purchasing, husbandry, recordkeeping, and basic physiologic and diagnostic screening in support of their research goals. The new Proteomics Unit offers modern protein analysis technology and services, from design and consultation to purification strategies for proteins of interest and clinical sample analysis. The Unit also assists Pis in the preparation of materials mass spectrometry. The Units of the RSC provide sophisticated services across the Co re-Center that are well suited for a common and centralized structure and function. This Core offers a high quality and accessible set of services to CNCS faculty that enhances the productivity of our research and stimulates interactions across laboratories. The attractive environment produced in turn catalyzes technological and scientific collaboration, and attracts new investigators to our labs and research goals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005409-08
Application #
8094319
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
8
Fiscal Year
2010
Total Cost
$171,008
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Jones, Sherri M; Vijayakumar, Sarath; Dow, Samantha A et al. (2018) Loss of ?-Calcitonin Gene-Related Peptide (?CGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance. Front Mol Neurosci 11:289
Walton, Joseph P; Dziorny, Adam C; Vasilyeva, Olga N et al. (2018) Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System. Front Cell Neurosci 12:291
Parks, Xiaorong Xu; Contini, Donatella; Jordan, Paivi M et al. (2017) Confirming a Role for ?9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista. Front Cell Neurosci 11:356
Bosen, Adam K; Fleming, Justin T; Allen, Paul D et al. (2017) Accumulation and decay of visual capture and the ventriloquism aftereffect caused by brief audio-visual disparities. Exp Brain Res 235:585-595
Bennetto, Loisa; Keith, Jessica M; Allen, Paul D et al. (2017) Children with autism spectrum disorder have reduced otoacoustic emissions at the 1 kHz mid-frequency region. Autism Res 10:337-345
Holt, J Chris; Jordan, Paivi M; Lysakowski, Anna et al. (2017) Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents. J Neurosci 37:1873-1887
Miller, Mark A; Crane, Benjamin T (2016) Static and dynamic visual vertical perception in subjects with migraine and vestibular migraine. World J Otorhinolaryngol Head Neck Surg 2:175-180
Bosen, Adam K; Fleming, Justin T; Brown, Sarah E et al. (2016) Comparison of congruence judgment and auditory localization tasks for assessing the spatial limits of visual capture. Biol Cybern 110:455-471
Jordan, Paivi M; Fettis, Margaret; Holt, Joseph C (2015) Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse. J Comp Neurol 523:1258-80
Karcz, Anita; Allen, Paul D; Walton, Joseph et al. (2015) Auditory deficits of Kcna1 deletion are similar to those of a monaural hearing impairment. Hear Res 321:45-51

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