The most compelling features of daily life include the ability to navigate through our environment and to communicate with each other. These functions are fundamental to survival, but are also among the first to encounter trouble in the diseased or aging nervous system. The University of Rochester holds a set of NIHsupported research programs dedicated to the sensory, motor, integrative, and cellular mechanisms underlying navigation and communication. Research ranges from molecular and genetic approaches to cellular neurophysiology in awake animals to human perception, and includes strong translational and clinical elements. These characteristics provide a compelling framework for our P-30, Center for Navigation and Communication Sciences (CNCS). New this past grant period, the CNCS is now operating at a steadystate that exceeds all expectations, largely due to committed leadership matched by a dedicated and engaged faculty and staff, cooperative and shared core services, a strong advisory and quality assurance process, and an infrastructure and community that has proven attractive to new collaborations and new investigators. The CNCS allows investigators to efficiently share costly, time-consuming, essential but cumbersome, and innovative research services. The CNCS includes three cores: 1) a Human Subjects Core to consolidate and coordinate the recruitment, screening, scheduling, and databasing of subjects across projects;2) a Research Services Core that includes a Histology &Imaging Unit (tissue preparation, image analysis & reconstruction), an Electronic/Mechanical Shop (repair and construction of lab components and devices), an Animal Research Unit (mutant and knockout preparations, husbandry and screening), and a Proteomics Unit (specialized protein analysis);and 3) a Technology and Computation Core, including a Lab Technology Unit (automated lab systems for stimulus and behavioral control, data acquisition, and data analysis) and a Computation Unit to support PC and network operations, software library, web support, and staff training. Some service units share support with the Department of Neurobiology &Anatomy, the Center for Visual Science (an NEI-P30), and two program projects (an NIA-P01 and an NINDS-P01). The CNCS exploits our inherently collegiate ecology and augments our lab capabilities through outstanding core personnel and facilities in dedicated space. All cores and units operate efficiently and balance the combined goals of providing both needed though sometimes mundane services as well as novel and innovative solutions that transform into tomorrow's capabilities. This ensures high-quality, efficient, and diverse services to all, in a robust infrastructure that enriches the productivity of our research, promotes collaborations among investigators, attracts new faculty and students to our research mission, facilitates further institutional support, and ultimately contributes to the health of the community and the nation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005409-08
Application #
8094320
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
8
Fiscal Year
2010
Total Cost
$35,387
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Jones, Sherri M; Vijayakumar, Sarath; Dow, Samantha A et al. (2018) Loss of ?-Calcitonin Gene-Related Peptide (?CGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance. Front Mol Neurosci 11:289
Walton, Joseph P; Dziorny, Adam C; Vasilyeva, Olga N et al. (2018) Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System. Front Cell Neurosci 12:291
Parks, Xiaorong Xu; Contini, Donatella; Jordan, Paivi M et al. (2017) Confirming a Role for ?9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista. Front Cell Neurosci 11:356
Bosen, Adam K; Fleming, Justin T; Allen, Paul D et al. (2017) Accumulation and decay of visual capture and the ventriloquism aftereffect caused by brief audio-visual disparities. Exp Brain Res 235:585-595
Bennetto, Loisa; Keith, Jessica M; Allen, Paul D et al. (2017) Children with autism spectrum disorder have reduced otoacoustic emissions at the 1 kHz mid-frequency region. Autism Res 10:337-345
Holt, J Chris; Jordan, Paivi M; Lysakowski, Anna et al. (2017) Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents. J Neurosci 37:1873-1887
Miller, Mark A; Crane, Benjamin T (2016) Static and dynamic visual vertical perception in subjects with migraine and vestibular migraine. World J Otorhinolaryngol Head Neck Surg 2:175-180
Bosen, Adam K; Fleming, Justin T; Brown, Sarah E et al. (2016) Comparison of congruence judgment and auditory localization tasks for assessing the spatial limits of visual capture. Biol Cybern 110:455-471
Jordan, Paivi M; Fettis, Margaret; Holt, Joseph C (2015) Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse. J Comp Neurol 523:1258-80
Karcz, Anita; Allen, Paul D; Walton, Joseph et al. (2015) Auditory deficits of Kcna1 deletion are similar to those of a monaural hearing impairment. Hear Res 321:45-51

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