Abstract

The Oregon Hearing Core Center (OHCC) will support seven principal investigators, funded by the NIDCD and other institutes, with a strong focus and a substantial record of accomplishments in the auditory and vestibular sciences. The goal of the OHCC is to centralize expertise on bioengineering, imaging, and mouse genetics in order to enhance presently funded research projects, including stimulating collaborations between participating investigators. In order to achieve these goals, three Core facilities are proposed. Core 1 (Bioengineering; Alfred Nuttall, director) will provide computer hardware and software support, as well as expertise and instrumentation for measurement of hearing acuity in live animals. Core 2 (Imaging; Dennis Trune and Peter Steyger, co-directors) will centralize confocal and electron-microscopic imaging through the existing OHRC infrastructure. Core 3 (Mouse Molecular Genetics; Peter Gillespie, director) will provide expertise on mouse husbandry and genotyping, as well as providing services for assembly of transgenic and gene-targeting constructs. By providing services not available through existing grants, this core facility will enhance research carried out by core-facility users and stimulate productive collaborations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005983-02
Application #
6733589
Study Section
Special Emphasis Panel (ZDC1-SRB-A (38))
Program Officer
Platt, Christopher
Project Start
2003-04-04
Project End
2008-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
2
Fiscal Year
2004
Total Cost
$603,429
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Wang, Lingyan; Kempton, J Beth; Brigande, John V (2018) Gene Therapy in Mouse Models of Deafness and Balance Dysfunction. Front Mol Neurosci 11:300
Oh, Yonghee; Reiss, Lina A J (2018) Binaural Pitch Fusion: Effects of Amplitude Modulation. Trends Hear 22:2331216518788972
Kachelmeier, Allan; Shola, Tsering; Meier, William B et al. (2018) Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells. PLoS One 13:e0206628
Krey, Jocelyn F; Dumont, Rachel A; Wilmarth, Philip A et al. (2018) ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci 38:843-857
Reiss, Lina A J; Fowler, Jennifer R; Hartling, Curtis L et al. (2018) Binaural Pitch Fusion in Bilateral Cochlear Implant Users. Ear Hear 39:390-397
Sheets, Lavinia; He, Xinyi J; Olt, Jennifer et al. (2017) Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset. J Neurosci 37:6299-6313
Reiss, Lina A J; Shayman, Corey S; Walker, Emily P et al. (2017) Binaural pitch fusion: Comparison of normal-hearing and hearing-impaired listeners. J Acoust Soc Am 141:1909
Erickson, Timothy; Morgan, Clive P; Olt, Jennifer et al. (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife 6:
Krey, J F; Wilmarth, P A; David, L L et al. (2017) Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry. Methods Enzymol 585:329-354
Adler, Henry J; Anbuhl, Kelsey L; Atcherson, Samuel R et al. (2017) Community network for deaf scientists. Science 356:386-387

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