The resume notes that the reviewers were enthusiastic about the 'innovative and state-of-the-art'Imaging Core, but also indicates some weaknesses, primarily the lack of a timetable for building the2-photon microscope and concern over the ability to hire and train the high-level specialist needed tostaff the facility. Concerns in individual reviews relate to the details of Core administration. Each ofthese issues is addressed in the revised plan:First, we provide a detailed timetable for the construction of the 2-photon microscope, which will takeabout four months. The timetable is based on recent experience constructing identical facilities.Second, we have recruited the high-level Imaging Specialist. Dr. Heather J. Rose has a Ph.D. inauditory cellular neurophysiology and currently is a postdoctoral fellow with Dr. Ian Parker studyingCa2+ transients using a 2-photon microscope. She has considerable experience with 2-photonimaging, including building instruments and conducting experiments, in vivo and in vitro. She iseminently qualified and is enthusiastic about this professional opportunity.Finally, additional details regarding Core administration are provided. In particular, we will establishan Advisory Committee to assist the Core director, Dr. Karina Cramer, in setting and evaluatingpriorities for use of Core resources. The P30 Director and Executive Committee will provide directionfor setting priorities and evaluating use of resources. The Advisory Committee will meet quarterly andwill consist of Dr. Parker as a permanent member, Dr. Rose, and an additional member to beselected from among Core users. Finally, we have provided information on the lack of similarfacilities on the UCI campus.
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