Our primary goal is to provide centralized and high-quality support for both basic and customized computing and engineering Service and training that can not only increase collaboration, efficiency and quality of existing research, but also stimulate new research in NIDCD mission areas at the University of California Irvine (UCI) and beyond. Our overall research strategy is to build upon and expand the service and support in computing arid engineering, according to the requests of the past, current and future core users with diverse backgrounds and needs. We have identified several common threads and developed signal processing tools, customized sound control, and formalized training to address these diverse backgrounds and needs. The present renewal application seeks to achieve the following three specific alms.
Aim 1 will provide signal processing the popular support for core users in stimulus generation and data processing.
Aim 2 will provide customized support for core users in sound control and prototype development. A highlight in Aim is collaboration with the Imaging core to build and integrate an ABR recording capability to be housed in the two-photo imaging facility.
Aim 3 will provide network and education support for core users and the hearing research community.
The proposed core activities are relevant to public health because they not only increase the efficiency and impact of innovative science performed by its users but also directly support translational research and education through prototype development and training. A significant goal of the present renewal is to increase the core's online presence, making signal processing tools and training materials available to researchers, clinicians, and the general public.
|Askew, Caitlin; Intskirveli, Irakli; Metherate, Raju (2017) Systemic Nicotine Increases Gain and Narrows Receptive Fields in A1 via Integrated Cortical and Subcortical Actions. eNeuro 4:|
|Zeng, Fan-Gang (2017) Challenges in Improving Cochlear Implant Performance and Accessibility. IEEE Trans Biomed Eng 64:1662-1664|
|Huang, Juan; Sheffield, Benjamin; Lin, Payton et al. (2017) Electro-Tactile Stimulation Enhances Cochlear Implant Speech Recognition in Noise. Sci Rep 7:2196|
|Dimitrijevic, Andrew; Alsamri, Jamal; John, M Sasha et al. (2016) Human Envelope Following Responses to Amplitude Modulation: Effects of Aging and Modulation Depth. Ear Hear 37:e322-35|
|Intskirveli, Irakli; Joshi, Anar; Vizcarra-Chacón, Bianca Julieta et al. (2016) Spectral breadth and laminar distribution of thalamocortical inputs to A1. J Neurophysiol 115:2083-94|
|Askew, Caitlin E; Metherate, Raju (2016) Synaptic interactions and inhibitory regulation in auditory cortex. Biol Psychol 116:4-9|
|Zeng, Fan-Gang; Djalilian, Hamid; Lin, Harrison (2015) Tinnitus treatment with precise and optimal electric stimulation: opportunities and challenges. Curr Opin Otolaryngol Head Neck Surg 23:382-7|
|Pham, Carol Q; Bremen, Peter; Shen, Weidong et al. (2015) Central Auditory Processing of Temporal and Spectral-Variance Cues in Cochlear Implant Listeners. PLoS One 10:e0132423|
|Rotschafer, Sarah E; Marshak, Sonya; Cramer, Karina S (2015) Deletion of Fmr1 alters function and synaptic inputs in the auditory brainstem. PLoS One 10:e0117266|
|Wynne, Dwight P; George, Sahara E; Zeng, Fan-Gang (2015) Amplitude modulation reduces loudness adaptation to high-frequency tones. J Acoust Soc Am 138:279-83|
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