The proposed Center for Molecular Auditory Neuroscience will enhance productivity, innovation, and collaborative interactions of auditory researchers at the University of Iowa. Center investigators are members of five clinical and basic science departments: Otolaryngology, Biology, Biochemistry, Physiology, and Communication Sciences and Disorders, with 15 auditory-related R01s, nine funded by NIDCD, a P50, two T32s, and other grants, for a total current year direct cost >$9M. There are extensive interactions among basic researchers, among clinical researchers, and interactions bridging clinical and basic research. The cores aim to strengthen these interactions and develop new ones. The Center consists of three research cores and will provide first-rate facilities for state-of-the-art experimental techniques crucial to molecular, cell, developmental and neurobiology of the inner ear;provide training in these techniques;make investigators aware of alternative experimental approaches and model systems that will facilitate their research;foster new collaborations that result in innovative approaches to problems in auditory research, including translation of basic research data to the clinic. The research cores are: (1) Histology and Imaging core to provide facilities and training for analysis of model organisms using light microscopy and EM: histology, including sectioning, staining, immunofluorescence, EM, and use of fluorescent dyes to label nerve fibers;confocal imaging, including multiphoton, of live or fixed tissue;(2) Genomics core for routine molecular biology techniques - sequencing, nucleotide synthesis, nucleic acid quantitation and quality - as well as analysis of gene expression;(3) Tissue/Cell Culture Core to provide facilities and training for preparation of in vitro cochlear model systems including sensory, neural and glial cells, organotypic inner ear cultures, and means for gene transfer into these cells. Individual experiments may use multiple cores and workflow will be coordinated among Core directors. The Administrative Core will manage day-to-day operation of the Center, coordinate activities of Core directors, and conduct symposia and seminars to facilitate interaction among the Center investigators.

Public Health Relevance

This P30 will support research interactions among a diverse group of investigators engaged in related questions of basic and clinical research: deafness genetics and gene therapy, inner ear development, sensorineural cell function and maintenance, cochlear implants. These are fundamental to prevention of deafness, optimization of current treatment of deafness, and to future cochlear sensorineural regeneration.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1-SRB-Q (68))
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Platt, Christopher
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University of Iowa
Schools of Arts and Sciences
Iowa City
United States
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Yang, Tian; Choi, Ji-Eun; Soh, Daniel et al. (2018) CaBP1 regulates Cav1 L-type Ca2+ channels and their coupling to neurite growth and gene transcription in mouse spiral ganglion neurons. Mol Cell Neurosci 88:342-352
Tuft, Bradley W; Xu, Linjing; Leigh, Braden et al. (2018) Photopolymerized micropatterns with high feature frequencies overcome chemorepulsive borders to direct neurite growth. J Tissue Eng Regen Med 12:e1392-e1403
Xu, Linjing; Seline, Alison E; Leigh, Braden et al. (2018) Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth. Otol Neurotol 39:119-126
Leigh, Braden L; Truong, Kristy; Bartholomew, Reid et al. (2017) Tuning Surface and Topographical Features to Investigate Competitive Guidance of Spiral Ganglion Neurons. ACS Appl Mater Interfaces 9:31488-31496
Chagnaud, Boris P; Engelmann, Jacob; Fritzsch, Bernd et al. (2017) Sensing External and Self-Motion with Hair Cells: A Comparison of the Lateral Line and Vestibular Systems from a Developmental and Evolutionary Perspective. Brain Behav Evol 90:98-116
Yang, Tian; Scholl, Elizabeth S; Pan, Ning et al. (2016) Expression and Localization of CaBP Ca2+ Binding Proteins in the Mouse Cochlea. PLoS One 11:e0147495
Saito, Yuhki; Miranda-Rottmann, Soledad; Ruggiu, Matteo et al. (2016) NOVA2-mediated RNA regulation is required for axonal pathfinding during development. Elife 5:
Dvorakova, Martina; Jahan, Israt; Macova, Iva et al. (2016) Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance. Sci Rep 6:38253
Fritzsch, Bernd; Duncan, Jeremy S; Kersigo, Jennifer et al. (2016) Neuroanatomical Tracing Techniques in the Ear: History, State of the Art, and Future Developments. Methods Mol Biol 1427:243-62
Li, Tongchao; Giagtzoglou, Nikolaos; Eberl, Daniel F et al. (2016) The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. Elife 5:

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