The primary expertise of Monell investigators spans a wide range of disciplines, including human sensory physiology and psychophysics (Drs. Breslin, Cowart, Dalton, Lundstrom, Pelchat, Mennella, Wysocki. Yamazaki. and Zhao), mouse and/or rat genefics (Drs. Bachmanov, Reed, and Tordoff), molecular biology (Drs. Brand, Margolskee, and Huang), and animal chemosensory physiology (Drs. Beauchamp, Lowe, Margolskee, and Reisert). Most or all of these research programs use DNA or RNA analysis methods at various fimes, but these methods often lie outside their area of expertise. This Core will serve to remove barriers from the invesfigators'use of these techniques. For instance, transgenic mice used by laboratories that study mouse behavior and physiology need to be genotyped to ensure that they are of the correct group (e.g., knockout or wild-type), but the invesfigator has no training in genotyping methods. Therefore, it is useful for the investigator to have a technician available who has been rigorously trained by experts to perform this work, to make use ofthe equipment available in the Core. Thus, not all people who study genefically engineered mice need to have all the equipment to genotype mice in their own laboratories. Likewise, invesfigators doing human sensory work might like to know their subject's genotype for key sensory polymorphisms (e.g., is the person homozygous for certain alleles associated with bitter taste blindness?). Again, this is often outside the expertise of their laboratory, but by working with this Core they can receive appropriate training and readily collect these data. Thus, this Core will provide a centralized common resource and reservoir of experience in genotyping and DNA/RNA analysis that would be inefficient to replicate in each individual laboratory. The availability of Core services extends the capabilifies of the participafing laboratories beyond what each could do individually.
| Lei, Weiwei; Ren, Wenwen; Ohmoto, Makoto et al. (2018) Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci U S A 115:5552-5557 |
| Freund, Jenna R; Mansfield, Corrine J; Doghramji, Laurel J et al. (2018) Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling. J Biol Chem 293:9824-9840 |
| Feng, Pu; Chai, Jinghua; Yi, Huilan et al. (2018) Aggravated gut inflammation in mice lacking the taste signaling protein ?-gustducin. Brain Behav Immun 71:23-27 |
| Qin, Yumei; Sukumaran, Sunil K; Jyotaki, Masafumi et al. (2018) Gli3 is a negative regulator of Tas1r3-expressing taste cells. PLoS Genet 14:e1007058 |
| Chang, Eugene H; Willis, Amanda L; McCrary, Hilary C et al. (2017) Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis. J Allergy Clin Immunol 139:1990-1992.e2 |
| Sukumaran, Sunil K; Lewandowski, Brian C; Qin, Yumei et al. (2017) Whole transcriptome profiling of taste bud cells. Sci Rep 7:7595 |
| Lipchock, Sarah V; Spielman, Andrew I; Mennella, Julie A et al. (2017) Caffeine Bitterness is Related to Daily Caffeine Intake and Bitter Receptor mRNA Abundance in Human Taste Tissue. Perception 46:245-256 |
| Hariri, Benjamin M; McMahon, Derek B; Chen, Bei et al. (2017) Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem 292:8484-8497 |
| Tordoff, Michael G; Pearson, Jordan A; Ellis, Hillary T et al. (2017) Does eating good-tasting food influence body weight? Physiol Behav 170:27-31 |
| Tomassini Barbarossa, Iole; Ozdener, M Hakan; Melania et al. (2017) Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people. Behav Brain Res 329:200-204 |
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