The Immunoassay Core (IA) provides Affiliate Investigators of the DERC with assays of peptides (insulin, proinsulin, C-peptide, Leptin, glucagon, pancreatic polypeptide) and antibodies (GAD65, ICA512, Insulin autoantibodies), performed under highly standardized conditions and with economies of scale unavailable to the individual investigator. During the past five-year funding period, the IA Core completed 18 projects for 16 Affiliate Investigators. At the present time, more than 35 projects are being supported for 34 Investigators. Work supported by the IA Core has, in this project period, resulted in over 215 publications in peer-review journals, and 19 book chapters. For the next project period, the IA Core will support at least 35 projects of 30 Affiliate Investigators. Assays are cost-effective for individual investigators; $5.00 is charged for measurements of insulin, C-peptide, $5.15 is charged for measurement of pancreatic polypeptide, glucagon, or proinsulin, GAD65 antibody and ICA512 (IA2) antibody level determinations, Leptin is charged at $6.40 and insulin autoantibody determination is charged at $7.40. In addition the Core laboratory provides insulin and glucagon radiolabeled tracer to Affiliate Investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK017047-27
Application #
6612277
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (O1))
Project Start
2002-12-01
Project End
2007-11-30
Budget Start
Budget End
2003-11-30
Support Year
27
Fiscal Year
2003
Total Cost
$138,172
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Mietlicki-Baase, Elizabeth G; Liberini, Claudia G; Workinger, Jayme L et al. (2018) A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents. Diabetes Obes Metab 20:1223-1234
Gordon, Sharona E; Munari, Mika; Zagotta, William N (2018) Visualizing conformational dynamics of proteins in solution and at the cell membrane. Elife 7:
Olivo, Robert E; Davenport, Clemontina A; Diamantidis, Clarissa J et al. (2018) Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study. Nephrol Dial Transplant 33:992-1001
Uusitalo, Ulla; Lee, Hye-Seung; Andrén Aronsson, Carin et al. (2018) Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care 41:522-530
Brault, Michelle; Olsen, Tayla M; Martinez, Jennifer et al. (2018) Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling. J Immunol 200:2748-2756
Hofsteen, Peter; Robitaille, Aaron Mark; Strash, Nicholas et al. (2018) ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience 2:88-100
Hippe, Daniel S; Phan, Binh An P; Sun, Jie et al. (2018) Lp(a) (Lipoprotein(a)) Levels Predict Progression of Carotid Atherosclerosis in Subjects With Atherosclerotic Cardiovascular Disease on Intensive Lipid Therapy: An Analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/ Arterioscler Thromb Vasc Biol 38:673-678
Subramanian, Savitha; Goodspeed, Leela; Wang, Shari et al. (2018) Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr-/- Mice. Int J Mol Sci 19:
James, Eddie A; Pietropaolo, Massimo; Mamula, Mark J (2018) Immune Recognition of ?-Cells: Neoepitopes as Key Players in the Loss of Tolerance. Diabetes 67:1035-1042
Liese, Angela D; Ma, Xiaonan; Ma, Xiaoguang et al. (2018) Dietary quality and markers of inflammation: No association in youth with type 1 diabetes. J Diabetes Complications 32:179-184

Showing the most recent 10 out of 1296 publications