Abstract

The Immunoassay Core (IA) provides Affiliate Investigators of the DERC with assays of peptides (insulin, proinsulin, C-peptide, Leptin, glucagon, pancreatic polypeptide) and antibodies (GAD65, ICA512, Insulin autoantibodies), performed under highly standardized conditions and with economies of scale unavailable to the individual investigator. During the past five-year funding period, the IA Core completed 18 projects for 16 Affiliate Investigators. At the present time, more than 35 projects are being supported for 34 Investigators. Work supported by the IA Core has, in this project period, resulted in over 215 publications in peer-review journals, and 19 book chapters. For the next project period, the IA Core will support at least 35 projects of 30 Affiliate Investigators. Assays are cost-effective for individual investigators; $5.00 is charged for measurements of insulin, C-peptide, $5.15 is charged for measurement of pancreatic polypeptide, glucagon, or proinsulin, GAD65 antibody and ICA512 (IA2) antibody level determinations, Leptin is charged at $6.40 and insulin autoantibody determination is charged at $7.40. In addition the Core laboratory provides insulin and glucagon radiolabeled tracer to Affiliate Investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK017047-27
Application #
6612277
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (O1))
Project Start
2002-12-01
Project End
2007-11-30
Budget Start
Budget End
2003-11-30
Support Year
27
Fiscal Year
2003
Total Cost
$138,172
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Mukamal, Kenneth J; Siscovick, David S; de Boer, Ian H et al. (2018) Metabolic Clusters and Outcomes in Older Adults: The Cardiovascular Health Study. J Am Geriatr Soc 66:289-296
Wall, Valerie Z; Barnhart, Shelley; Kanter, Jenny E et al. (2018) Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome. JCI Insight 3:
Toledo, Frederico G S; Johannsen, Darcy L; Covington, Jeffrey D et al. (2018) Impact of prolonged overfeeding on skeletal muscle mitochondria in healthy individuals. Diabetologia 61:466-475
Ferreccio, Amy; Mathieu, Julie; Detraux, Damien et al. (2018) Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Cell Cycle 17:535-549
Tang, Jingjing; Frey, Jeremy M; Wilson, Carole L et al. (2018) Neutrophil and macrophage cell surface CSF-1 shed by ADAM17 drives mouse macrophage proliferation in acute and chronic inflammation. Mol Cell Biol :
Lynch, Kristian F; Lee, Hye-Seung; Törn, Carina et al. (2018) Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident ?-cell autoantibodies. J Autoimmun 86:93-103
Parilla, Jacqueline H; Willard, Joshua R; Barrow, Breanne M et al. (2018) A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes. J Diabetes Res 2018:6106051
Bornfeldt, Karin E; Kramer, Farah; Batorsky, Anna et al. (2018) A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis. Am J Pathol 188:343-352
Wang, Ke; Zelnick, Leila R; Hoofnagle, Andrew N et al. (2018) Alteration of HDL Protein Composition with Hemodialysis Initiation. Clin J Am Soc Nephrol 13:1225-1233
Bharmal, Nazleen H; McCarthy, William J; Gadgil, Meghana D et al. (2018) The Association of Religious Affiliation with Overweight/Obesity Among South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. J Relig Health 57:33-46

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