The Cellular and Molecular Imaging Core, which had its origin in 1977, facilitates the outstanding and innovative research of Diabetes Research Center affiliates in the Seattle area by keeping pace with and pioneering new methodological and technical advances in histochemistry, microscopic imaging and image analysis. In the next funding cycle the CMIC will continue to promote the research of these investigators during the next funding cycle by providing: (1) Quantitative assessment of immunohistochemistry and morphological changes in tissues; (2) Access to state-of-the-art imaging instrumentation, in a cost-effective manner; (3) Expert diabetes-related technical and scientific support, including design of research protocols and interpretation of results; (4) Access to comparative pathologists, to assist with experimental and/or preclinical studies; and (5) Hands-on and didactic training to affiliates, their trainees and personnel with routine and highly specialized morphological, histochemical and imaging techniques. Through all of these services, the Cellular and Molecular Imaging Core places a great deal of emphasis on ensuring high standards of rigor and reproducibility for studies undertaken in the Core. This includes, but is not limited to, rigorous quality control for reagents, expert review of protocols and ensuring appropriate and adequate use of positive and negative controls. By achieving these goals, the Cellular and Molecular Imaging Core will support the scientific investigation of affiliate investigators who will use the core to further our understanding of diabetes, obesity and related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK017047-45
Application #
10077861
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2018-02-10
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Banks, William A; Kovac, Andrej; Morofuji, Yoichi (2018) Neurovascular unit crosstalk: Pericytes and astrocytes modify cytokine secretion patterns of brain endothelial cells. J Cereb Blood Flow Metab 38:1104-1118
de Groot, Mary; Marrero, David; Mele, Lisa et al. (2018) Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program. Psychosom Med 80:167-173
Roshandel, Delnaz; Gubitosi-Klug, Rose; Bull, Shelley B et al. (2018) Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes. Diabetologia 61:1098-1111
Hannon, Tamara S; Kahn, Steven E; Utzschneider, Kristina M et al. (2018) Review of methods for measuring ?-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium. Diabetes Obes Metab 20:14-24
Brinkley, Tina E; Anderson, Andrea; Soliman, Elsayed Z et al. (2018) Long-Term Effects of an Intensive Lifestyle Intervention on Electrocardiographic Criteria for Left Ventricular Hypertrophy: The Look AHEAD Trial. Am J Hypertens 31:541-548
Kanter, Jenny E; Kramer, Farah; Barnhart, Shelley et al. (2018) A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome. Diabetes 67:946-959
Redondo, Maria J; Geyer, Susan; Steck, Andrea K et al. (2018) TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care 41:311-317
Guillory, Bobby; Jawanmardi, Nicole; Iakova, Polina et al. (2018) Ghrelin deletion protects against age-associated hepatic steatosis by downregulating the C/EBP?-p300/DGAT1 pathway. Aging Cell 17:
RISE Consortium (2018) Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care 41:1717-1725
Osoti, Alfred; Temu, Tecla M; Kirui, Nicholas et al. (2018) Metabolic Syndrome Among Antiretroviral Therapy-Naive Versus Experienced HIV-Infected Patients Without Preexisting Cardiometabolic Disorders in Western Kenya. AIDS Patient Care STDS 32:215-222

Showing the most recent 10 out of 1296 publications