Abstract

This renewal application requests 5 year support for a DERC grant to continue a broad and intensive research program that is now in its 13th year and involving close to 100 scientists who investigate Diabetes Mellitus and related metabolic and endocrine disorders. As in the past, five scientific cores are proposed. Yet, three of those are new or restructured to respond to modern trends of biochemical research and changing needs of DERC investigators. These cores are: 1) An Antibody Production Core; 2) An Electron Microscopy/Morphology Core; 3) A Pancreatic Islet Cell Core; 4) A Protein and Nucleic Acid Chemistry Core; and 5) A Radioimmunoassay Core. These scientific cores will considerably enhance the productivity and interdisciplinary collaboration of Center investigators and will allow them to apply the most modern approaches of biomedical research which are not available to individual laboratories. The application also requests support for an Administrative Core which will be responsible for an intensive Academic Enrichment and a Visiting Scientist Program and will greatly facilitate the interdisciplinary interaction of Center investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK019525-15
Application #
3101936
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1977-03-01
Project End
1996-02-29
Budget Start
1991-03-01
Budget End
1992-02-28
Support Year
15
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Wangensteen, Kirk J; Wang, Yue J; Dou, Zhixun et al. (2018) Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology 68:663-676
Brown, Justin C; Damjanov, Nevena; Courneya, Kerry S et al. (2018) A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors. Psychooncology 27:1221-1228
Wooldridge, Amy L; Bischof, Robert J; Liu, Hong et al. (2018) Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am J Physiol Regul Integr Comp Physiol 314:R22-R33
Kim, Boa; Jang, Cholsoon; Dharaneeswaran, Harita et al. (2018) Endothelial pyruvate kinase M2 maintains vascular integrity. J Clin Invest 128:4543-4556
Gibson, Christopher E; Boodhansingh, Kara E; Li, Changhong et al. (2018) Congenital Hyperinsulinism in Infants with Turner Syndrome: Possible Association with Monosomy X and KDM6A Haploinsufficiency. Horm Res Paediatr 89:413-422
Hill, David A; Lim, Hee-Woong; Kim, Yong Hoon et al. (2018) Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proc Natl Acad Sci U S A 115:E5096-E5105
Kim, Yong Hoon; Marhon, Sajid A; Zhang, Yuxiang et al. (2018) Rev-erb? dynamically modulates chromatin looping to control circadian gene transcription. Science 359:1274-1277
Mowel, Walter K; Kotzin, Jonathan J; McCright, Sam J et al. (2018) Control of Immune Cell Homeostasis and Function by lncRNAs. Trends Immunol 39:55-69
Rickels, Michael R; Peleckis, Amy J; Dalton-Bakes, Cornelia et al. (2018) Continuous Glucose Monitoring for Hypoglycemia Avoidance and Glucose Counterregulation in Long-Standing Type 1 Diabetes. J Clin Endocrinol Metab 103:105-114
Guan, Dongyin; Xiong, Ying; Borck, Patricia C et al. (2018) Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell 174:831-842.e12

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