Abstract

This renewal application requests 5 year support for a DERC grant to continue a broad and intensive research program that is now in its 13th year and involving close to 100 scientists who investigate Diabetes Mellitus and related metabolic and endocrine disorders. As in the past, five scientific cores are proposed. Yet, three of those are new or restructured to respond to modern trends of biochemical research and changing needs of DERC investigators. These cores are: 1) An Antibody Production Core; 2) An Electron Microscopy/Morphology Core; 3) A Pancreatic Islet Cell Core; 4) A Protein and Nucleic Acid Chemistry Core; and 5) A Radioimmunoassay Core. These scientific cores will considerably enhance the productivity and interdisciplinary collaboration of Center investigators and will allow them to apply the most modern approaches of biomedical research which are not available to individual laboratories. The application also requests support for an Administrative Core which will be responsible for an intensive Academic Enrichment and a Visiting Scientist Program and will greatly facilitate the interdisciplinary interaction of Center investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK019525-19
Application #
2137342
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1977-03-01
Project End
1997-02-28
Budget Start
1995-03-01
Budget End
1996-02-29
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Pickett-Blakely, Octavia; Young, Kimberly; Carr, Rotonya M (2018) Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis. Cell Mol Gastroenterol Hepatol 6:451-462
Kameswaran, Vasumathi; Golson, Maria L; Ramos-Rodríguez, Mireia et al. (2018) The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs. Diabetes 67:1807-1815
Huang, Chen; Walker, Emily M; Dadi, Prasanna K et al. (2018) Synaptotagmin 4 Regulates Pancreatic ? Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell 45:347-361.e5
Moreira, Leticia; Bakir, Basil; Chatterji, Priya et al. (2018) Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 5:289-298
Pei, Liming; Wallace, Douglas C (2018) Mitochondrial Etiology of Neuropsychiatric Disorders. Biol Psychiatry 83:722-730
Brown, Justin C; Rickels, Michael R; Troxel, Andrea B et al. (2018) Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer 25:11-19
Rickels, M R; Markmann, E; Naji, A (2018) Successful pregnancies after islet transplantation for type 1 diabetes. Am J Transplant :
Friedman, Elliot S; Li, Yun; Shen, Ting-Chin David et al. (2018) FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155:1741-1752.e5
Rickels, Michael R; DuBose, Stephanie N; Toschi, Elena et al. (2018) Mini-Dose Glucagon as a Novel Approach to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes. Diabetes Care 41:1909-1916
Jang, Cholsoon; Hui, Sheng; Lu, Wenyun et al. (2018) The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab 27:351-361.e3

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