The mission of the Pilot and Feasibility Program (P&F) of the Penn DRC is foster the development of new investigators and to provide seed-support for innovative high-risk diabetes-related projects, with an increasing emphasis on clinical and translational science. Over the past 2 funding periods (10 years), the Pilot and Feasibility Program has been highly successful in this regard. 39 investigators received P&F Awards and, of these, 34 (87%) have garnered NIH support, the majority as R01s directly related to their Pilot Awards. During the previous funding period 30 grants were awarded from among 115 applications submitted by investigators representing 22 Departments spanning multiple Schools and Institutes on the campus of the University of Pennsylvania and other Philadelphia institutions. Of the funded grants, nearly 80% were to new investigators and more than 25% were dedicated to clinical and translational projects. During the next funding period we propose to continue the core mission of the Pilot and Feasibility Program. Given the past successes of the program, the increased cost of performing research in the setting of a more competitive general funding environment, and the clear need based on the escalating numbers of applications from new and established investigators both within and outside of the diabetes research community, we feel that this program continues to be well justified. We also propose to administer one additional Pilot and Feasibility Award dedicated to the use of the exciting new Regional Metabolomics Core at Princeton University that is proposed in this application and consistent with the P&F mission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK019525-38
Application #
8638936
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
38
Fiscal Year
2014
Total Cost
$363,917
Indirect Cost
$119,999
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Huang, Chen; Walker, Emily M; Dadi, Prasanna K et al. (2018) Synaptotagmin 4 Regulates Pancreatic ? Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell 45:347-361.e5
Moreira, Leticia; Bakir, Basil; Chatterji, Priya et al. (2018) Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 5:289-298
Pei, Liming; Wallace, Douglas C (2018) Mitochondrial Etiology of Neuropsychiatric Disorders. Biol Psychiatry 83:722-730
Brown, Justin C; Rickels, Michael R; Troxel, Andrea B et al. (2018) Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer 25:11-19
Rickels, M R; Markmann, E; Naji, A (2018) Successful pregnancies after islet transplantation for type 1 diabetes. Am J Transplant :
Friedman, Elliot S; Li, Yun; Shen, Ting-Chin David et al. (2018) FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155:1741-1752.e5
Rickels, Michael R; DuBose, Stephanie N; Toschi, Elena et al. (2018) Mini-Dose Glucagon as a Novel Approach to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes. Diabetes Care 41:1909-1916
Jang, Cholsoon; Hui, Sheng; Lu, Wenyun et al. (2018) The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab 27:351-361.e3
Juliana, Christine A; Yang, Juxiang; Cannon, Corey E et al. (2018) A PDX1-ATF transcriptional complex governs ? cell survival during stress. Mol Metab 17:39-48
McKee, Sarah E; Zhang, Sisi; Chen, Li et al. (2018) Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J Neurochem 145:362-373

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