Metabolomics Core The goals of the Metabolomics Core are to: 1. Provide consultation and training in metabolomic analysis. 2. Enable access to state-of-the-art instrumentation and services for metabolomic analysis. 3. Provide access to highly skilled personnel to aid in the analysis and interpretation of metabolomic data. 4. Develop and/or implement new technologies for metabolomics analysis beneficial to MDRC investigators. The Core owns, maintains, and operates a panel of MS and other instruments that are used to analyze metabolism and to perform metabolomic analyses. The Core accomplishes its goals by providing access to senior personnel versed in the use of technologies for metabolomic analysis. In addition Core personel provide consultation/guidance/training in the use of metabolomic analysis for MDRC members. The Core performs metabolomic analysis of specific metabolites and/or undirected metabolite analysis, and provides subsidies to reduce the cost of accessing these services for MDRC members, thus enhacing the research programs of all MDRC members (at all affilaited institutions) who have need of these services for their diabetes-related research.

Public Health Relevance

This research is relevant to the public health because it will increase our understanding of the events, at the level of changes metabolites, that underiie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
4P30DK020572-39
Application #
8988561
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
39
Fiscal Year
2016
Total Cost
$69,583
Indirect Cost
$24,835
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Spencer, Michael S; Kieffer, Edith C; Sinco, Brandy et al. (2018) Outcomes at 18 Months From a Community Health Worker and Peer Leader Diabetes Self-Management Program for Latino Adults. Diabetes Care 41:1414-1422
Sujkowski, Alyson; Wessells, Robert (2018) Using Drosophila to Understand Biochemical and Behavioral Responses to Exercise. Exerc Sport Sci Rev 46:112-120
Brown, Rebecca J; Oral, Elif A; Cochran, Elaine et al. (2018) Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy. Endocrine 60:479-489
Lee, Pearl G; Damschroder, Laura J; Holleman, Robert et al. (2018) Older Adults and Diabetes Prevention Programs in the Veterans Health Administration. Diabetes Care 41:2644-2647
McEwen, Laura N; Lee, Pearl G; Backlund, Jye-Yu C et al. (2018) Recording of Diabetes on Death Certificates of Decedents With Type 1 Diabetes in DCCT/EDIC. Diabetes Care 41:e158-e160
Ramos, Carla J; Lin, Chengmao; Liu, Xuwen et al. (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293:717-730
Ma, Fuqiang; Chung, Meng Ting; Yao, Yuan et al. (2018) Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform. Nat Commun 9:1030
Pieber, Thomas R; Marso, Steven P; McGuire, Darren K et al. (2018) DEVOTE 3: temporal relationships between severe hypoglycaemia, cardiovascular outcomes and mortality. Diabetologia 61:58-65
Burghardt, Kyle J; Goodrich, Jacyln M; Lines, Brittany N et al. (2018) The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. Int J Genomics 2018:8076397
Klueh, Ulrike; Ludzinska, Izabela; Czajkowski, Caroline et al. (2018) Crosslinked basement membrane-based coatings enhance glucose sensor function and continuous glucose monitoring in vivo. J Biomed Mater Res A 106:7-16

Showing the most recent 10 out of 1823 publications