The prevalence of diabetes mellitus in the United States is reaching epidemic proportions and accounts for a huge national burden of morbidity, mortality, and health care expenditures. The Michigan Diabetes Research center (MDRC) builds on the 35-year experience of the Michigan Diabetes Research and Training Center (MDRTC) as a key component of the research effort to promote new discoveries and enhance scientific progress through support of cutting-edge basic and clinical research related to the etiology and complications of diabetes. The goal of the MDRC Is to establish, promote, and enhance multidisciplinary and collaborative basic biomedical and clinical research among member investigators studying diabetes, its complications, and related endocrine and metabolic disorders. The missions of the MDRC are to create an environment that supports important and innovative research; raise awareness and Interest In fundamental and clinical diabetes research at affiliated Institutions and beyond; enhance diabetes research education and training opportunities for patients, students, scientists, and clinicians; attract an retain early stage Investigators and Investigators new to diabetes research; provide core services that leverage funding and unique expertise; foster interdisciplinary collaborations, especially In the emerging areas of research, to catalyze new ideas and scientific approaches; and promote the translation of scientific discoveries from bench to bedside to community to Improve public health.

Public Health Relevance

The MDRC promotes and enhances multidisciplinary and collaborative basic and clinical research relevant to diabetes, its complications, and related endocrine and metabolic disorders. This serves to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and clinical research to prevent, treat, and ultimately cure diabetes and its complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK020572-40S1
Application #
9526628
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2018-02-26
Budget Start
2016-12-01
Budget End
2018-02-26
Support Year
40
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Allison, Margaret B; Pan, Warren; MacKenzie, Alexander et al. (2018) Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action. Diabetes 67:1093-1104
Meng, Zhuo-Xian; Tao, Weiwei; Sun, Jingxia et al. (2018) Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle. Diabetes 67:85-97
Burghardt, Kyle J; Seyoum, Berhane; Mallisho, Abdullah et al. (2018) Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies. Prog Neuropsychopharmacol Biol Psychiatry 83:55-63
Wang, Ting; Pehrsson, Erica C; Purushotham, Deepak et al. (2018) The NIEHS TaRGET II Consortium and environmental epigenomics. Nat Biotechnol 36:225-227
Burghardt, Kyle J; Seyoum, Berhane; Dass, Sabrina E et al. (2018) Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder. Pharmacotherapy 38:428-435
Yu, Sangho; Cheng, Helia; François, Marie et al. (2018) Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife 7:
Ray, Debashree; Boehnke, Michael (2018) Methods for meta-analysis of multiple traits using GWAS summary statistics. Genet Epidemiol 42:134-145
Pesch, Megan H; Miller, Alison L; Appugliese, Danielle P et al. (2018) Mothers of Obese Children Use More Direct Imperatives to Restrict Eating. J Nutr Educ Behav 50:403-407.e1
Pan, Warren; Adams, Jessica M; Allison, Margaret B et al. (2018) Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology 159:1860-1872
Sherman, Shermel B; Sarsour, Nadeen; Salehi, Marziyeh et al. (2018) Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. Gut Microbes 9:400-421

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