- Clinical Core The Clinical Core of the Michigan Diabetes Research Center (MDRC) provides resources and expertise to enhance the effectiveness, efficiency, and multidisciplinary nature of clinical research performed by MDRC investigators. Specifically, the Clinical Core provides resources and expertise to support type 1 translational research that focuses on moving basic science discovery and preclinical development into people with diabetes in order to enhance human health and well-being. This bench-to-bedside process may involve testing new drugs, devices, or treatment programs for patients at risk for or with diabetes and its complications and comorbidities or with related metabolic and endocrine disorders. The MDRC Clinical Core provides MDRC clinical investigators: ? Well?equipped and accessible clinical research space for diabetes-related studies, ? Expertise and resources to facilitate the recruitment of diabetic subjects into clinical studies, ? A chemistry laboratory to provide expertise and state-of-the-art laboratory analytical services, and ? Biostatistical services to address experimental design, data management, and data analysis. Since its creation five years ago, the Clinical Core has adapted to the changing University of Michigan (UM) research environment and the evolving needs of MDRC investigators to provide ready access to well-equipped research space and to expand access to potential research subjects using tools made possible by the implementation of the new UM electronic medical record. In addition, the Clinical Core has rolled out new laboratory services with excellent quality control and low cost. It has also brought on new staff to assist with study design, data management, and data analysis. All of these services are designed to facilitate diabetes- related clinical research and collaboration. Discoveries made at a molecular or whole animal level can be tested in human subjects using the resources of the Clinical Core. Similarly, observations made using Clinical Core resources can be understood at a more detailed and mechanistic level using resources provided by MDRC biomedical research cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020572-44
Application #
10071176
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1996-12-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
44
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Yue, Yang; Blasius, T Lynne; Zhang, Stephanie et al. (2018) Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. J Cell Biol 217:1319-1334
Ammari, Zaid; Pak, Stella C; Ruzieh, Mohammed et al. (2018) Posttransplant Tacrolimus-Induced Diabetic Ketoacidosis: Review of the Literature. Case Rep Endocrinol 2018:4606491
Brown, Callie L; Perrin, Eliana M; Peterson, Karen E et al. (2018) Association of Picky Eating With Weight Status and Dietary Quality Among Low-Income Preschoolers. Acad Pediatr 18:334-341
Kimball, Andrew; Schaller, Matthew; Joshi, Amrita et al. (2018) Ly6CHi Blood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes Mellitus. Arterioscler Thromb Vasc Biol 38:1102-1114
Lee, Jin-Sook; Caruso, Joseph A; Hubbs, Garrett et al. (2018) Molecular architecture of mouse and human pancreatic zymogen granules: protein components and their copy numbers. Biophys Rep 4:94-103
Jiang, Youde; Liu, Li; Steinle, Jena J (2018) miRNA15a regulates insulin signal transduction in the retinal vasculature. Cell Signal 44:28-32
Montrose, Luke; Padmanabhan, Vasantha; Goodrich, Jaclyn M et al. (2018) Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation. Epigenetics 13:301-309
Afshinnia, Farsad; Rajendiran, Thekkelnaycke M; Wernisch, Stefanie et al. (2018) Lipidomics and Biomarker Discovery in Kidney Disease. Semin Nephrol 38:127-141
Rodriquez, Erik J; Livaudais-Toman, Jennifer; Gregorich, Steven E et al. (2018) Relationships between allostatic load, unhealthy behaviors, and depressive disorder in U.S. adults, 2005-2012 NHANES. Prev Med 110:9-15
Morran, Michael P; Al-Dieri, Ali G; Nestor-Kalinoski, Andrea L et al. (2018) Insulin receptor based lymphocyte trafficking in the progression of type 1 diabetes. J Biol Methods 5:

Showing the most recent 10 out of 1823 publications