- Clinical Core The Clinical Core of the Michigan Diabetes Research Center (MDRC) provides resources and expertise to enhance the effectiveness, efficiency, and multidisciplinary nature of clinical research performed by MDRC investigators. Specifically, the Clinical Core provides resources and expertise to support type 1 translational research that focuses on moving basic science discovery and preclinical development into people with diabetes in order to enhance human health and well-being. This bench-to-bedside process may involve testing new drugs, devices, or treatment programs for patients at risk for or with diabetes and its complications and comorbidities or with related metabolic and endocrine disorders. The MDRC Clinical Core provides MDRC clinical investigators: ? Well?equipped and accessible clinical research space for diabetes-related studies, ? Expertise and resources to facilitate the recruitment of diabetic subjects into clinical studies, ? A chemistry laboratory to provide expertise and state-of-the-art laboratory analytical services, and ? Biostatistical services to address experimental design, data management, and data analysis. Since its creation five years ago, the Clinical Core has adapted to the changing University of Michigan (UM) research environment and the evolving needs of MDRC investigators to provide ready access to well-equipped research space and to expand access to potential research subjects using tools made possible by the implementation of the new UM electronic medical record. In addition, the Clinical Core has rolled out new laboratory services with excellent quality control and low cost. It has also brought on new staff to assist with study design, data management, and data analysis. All of these services are designed to facilitate diabetes- related clinical research and collaboration. Discoveries made at a molecular or whole animal level can be tested in human subjects using the resources of the Clinical Core. Similarly, observations made using Clinical Core resources can be understood at a more detailed and mechanistic level using resources provided by MDRC biomedical research cores.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Adams, Jessica M; Pei, Hongjuan; Sandoval, Darleen A et al. (2018) Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes 67:1538-1548
Fernandez, Carmen; DeJesus, Jasmine M; Miller, Alison L et al. (2018) Selective eating behaviors in children: An observational validation of parental report measures. Appetite 127:163-170
Zhang, Sherry; Lu, Chunxia; Das, Arun K et al. (2018) Abrogation of GH action in Kupffer cells results in increased hepatic CD36 expression and exaggerated nonalcoholic fatty liver disease. Growth Horm IGF Res 42-43:74-79
Mishra, Manish; Duraisamy, Arul J; Kowluru, Renu A (2018) Sirt1: A Guardian of the Development of Diabetic Retinopathy. Diabetes 67:745-754
Sas, Kelli M; Lin, Jiahe; Rajendiran, Thekkelnaycke M et al. (2018) Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model. J Lipid Res 59:173-183
Zhang, Peng; Kuang, Henry; He, Yanlin et al. (2018) NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight 3:
Rosenstock, Julio; Perkovic, Vlado; Alexander, John H et al. (2018) Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardi Cardiovasc Diabetol 17:39
Kady, Nermin M; Liu, Xuwen; Lydic, Todd A et al. (2018) ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes 67:769-781
Jaiswal, Mamta; Divers, Jasmin; Urbina, Elaine M et al. (2018) Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. Pediatr Diabetes 19:680-689
Rios, Peter D; Skoumal, Michael; Liu, Jeffrey et al. (2018) Evaluation of encapsulating and microporous nondegradable hydrogel scaffold designs on islet engraftment in rodent models of diabetes. Biotechnol Bioeng 115:2356-2364

Showing the most recent 10 out of 1823 publications