The Immunology of Type 1 Diabetes Core provides logistic support to investigators examining autoimmune or type 1 diabetes or other endocrine autoimmunities. The Core is centered in the Department of Pathology and Immunology. The Core provides: i) assistance in the maintenance of various inbred mouse lines, including conventional non-obese diabetic (NOD) mice and NOD lines in which a variety of immune-relevant molecules has been deleted;ii) training in the maintenance and testing of diabetogenic strains;iii) expertise in, and training for, the isolation and examination of islets of Langerhans;iv) services for the generation of new diabetogenic mouse strains using Balb/c and NOD embryonic stem cells;and v) provision of isolated cells, cell lines, and monoclonal antibodies relevant for immunological research. During the past funding cycle, services were provided to 31 investigators, which represents a doubling of service provided compared to the prior funding cycle. This reflects, in part, increased utilization of the most frequently requested service, maintenance and provision of inbred strains. The increase also reflects the new services for provision of cell lines, isolated immune cells, antibodies and peptides. The Core provides service to and has helped to cultivate a diverse group of investigators at Washington University with a commitment to studying the pathogenesis and treatment of type 1 diabetes. Services from this Core were instrumental in facilitating high impact studies of the immunobiology of type 1 diabetes.

Public Health Relevance

The Core provides services to facilitate the investigations of immunologists and diabetologists working to understand the pathogenesis of type 1 diabetes. The Core services are particulariy useful to faculty starting their own laboratories, or to faculty wishing to carry out pilot studies using autoimmune propensity mice. Importantly, this Core provides assistance with highly specialized immune models of type 1 diabetes that can be difficult to generate and propagate.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S)
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Washington University
Saint Louis
United States
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Wang, Songyan; Oestricker, Lauren Z; Wallendorf, Michael J et al. (2018) Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance. PLoS One 13:e0192441
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :
Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun et al. (2018) Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring) 26:683-688
Higgins, Cassandra B; Zhang, Yiming; Mayer, Allyson L et al. (2018) Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR?. JCI Insight 3:
Cahill, Alison G; Haire-Joshu, Debra; Cade, W Todd et al. (2018) Weight Control Program and Gestational Weight Gain in Disadvantaged Women with Overweight or Obesity: A Randomized Clinical Trial. Obesity (Silver Spring) 26:485-491
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 97:1284-1298.e7
Rajagopal, Rithwick; Zhang, Sheng; Wei, Xiaochao et al. (2018) Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:
Frankfater, Cheryl; Jiang, Xuntian; Hsu, Fong-Fu (2018) Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry. J Am Soc Mass Spectrom 29:1688-1699
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Rimer, Jamie M; Lee, Jiyeon; Holley, Christopher L et al. (2018) Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. J Biol Chem 293:13284-13296

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