Translational Diagnostics Core The long-term goal of the Washington University Diabetes Research Center (DRC) Translational Diagnostics Core is to improve human health by supporting clinical laboratory testing services for research in diabetes mellitus and related metabolic disorders. Most Core analyses are performed on samples from human studies and some are performed on samples from animal models. The Core provides expert consultation to investigators so that the most appropriate tests can be chosen while taking cost and number of samples into consideration. In addition to quantification of classic metabolic analytes relevant to diabetes, such as insulin and glucagon, the core also offers assays for diabetes and metabolism relevant molecules, such as adiponectin and TNF?. For some special analytes, the Core maintains contracts with Quest Diagnostics and Mayo Medical Laboratories, so that these analyses can be performed at substantially lower cost to DRC members. Development of new research tests is another important activity of the Translational Diagnostics Core, which makes available to DRC members analyses with enhanced sensitivity and accuracy that incorporate the latest advances in diabetes and metabolism research. The Translational Diagnostics Core provides efficient, high quality diagnostic services promoting the translation of basic scientific discoveries for the prevention, treatment and cure of diabetes and its complications. .

Public Health Relevance

Translational Diagnostics Core The Washington University Diabetes Research Center Translational Diagnostics Core performs efficient clinical laboratory testing to support research in the field of diabetes mellitus. The primary goals of the Core are to reduce the high costs of specialty testing and to provide outstanding quality control so that reliable diabetes- related tests are widely available to investigators focused on the pathogenesis, treatment and cure of diabetes and related metabolic disorders.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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Washington University
Saint Louis
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Goldner, Nicholas K; Bulow, Christopher; Cho, Kevin et al. (2018) Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum. mSphere 3:
Lin, Jonathan B; Sene, Abdoulaye; Santeford, Andrea et al. (2018) Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging. EBioMedicine 32:9-20
Tuttle, Lori J; Bittel, Daniel C; Bittel, Adam J et al. (2018) Early-Onset Physical Frailty in Adults With Diabesity and Peripheral Neuropathy. Can J Diabetes 42:478-483
Song, Wilbur M; Joshita, Satoru; Zhou, Yingyue et al. (2018) Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med 215:745-760
Musselman, Laura Palanker; Fink, Jill L; Maier, Ezekiel J et al. (2018) Seven-Up Is a Novel Regulator of Insulin Signaling. Genetics 208:1643-1656
Riek, Amy E; Oh, Jisu; Darwech, Isra et al. (2018) Vitamin D3 supplementation decreases a unique circulating monocyte cholesterol pool in patients with type 2 diabetes. J Steroid Biochem Mol Biol 177:187-192
Peterson, Linda R; Xanthakis, Vanessa; Duncan, Meredith S et al. (2018) Ceramide Remodeling and Risk of Cardiovascular Events and Mortality. J Am Heart Assoc 7:
Bittel, Adam J; Bohnert, Kathryn L; Reeds, Dominic N et al. (2018) Reduced Muscle Strength in Barth Syndrome May Be Improved by Resistance Exercise Training: A Pilot Study. JIMD Rep :
Hampton, Kaia K; Anderson, Katie; Frazier, Hilaree et al. (2018) Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1. Mol Pharmacol 94:665-673
Ferguson, Daniel; Blenden, Mitchell; Hutson, Irina et al. (2018) Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity and Metabolic Complications. Endocrinology 159:3275-3286

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