Center Overview The mission of the Washington University School of Medicine (WUSM) Diabetes Research Center (DRC) is to support and enhance research in diabetes and related metabolic diseases. The DRC accomplishes this mission through Biomedical Research Core services reflecting the evolving needs of diabetes investigators, vibrant Pilot & Feasibility Programs, and a dynamic Enrichment Program. Now in its 40th year of continuous NIDDK funding, this DRC is located at an outstanding research institution with a longstanding tradition of excellence in diabetes investigation. The WUSM DRC Research Base is organized in four Focus Groups: Metabolic Regulation, Islet Biology & Immunology, Prevention & Epidemiology, and Complications. Investigators from each group participate in DRC programs that address the Center's central scientific theme of enhancing approaches across the translational spectrum. There is compelling evidence that the WUSM DRC is successfully pursuing its mission of supporting and enhancing research, including outstanding productivity as measured by both by scientific publications and peer-reviewed funding in diabetes and related research. Our research strategy will build on these accomplishments by: 1. Creating an environment that supports important as well as innovative research in diabetes and related metabolic disorders; 2. Supporting cutting edge basic and clinical research related to the etiology, pathogenesis, prevention and cure of diabetes; 3. Raising awareness and interest in fundamental and clinical diabetes research in addition to enhancing multidisciplinary approaches to diabetes and its complications; and 4. Translating new knowledge in diabetes to improved treatment of patients with diabetes.
Center Overview Diabetes and related metabolic disorders of obesity, insulin resistance, and metabolic syndrome are complex, systemic conditions involving environmental and genetic influences. The infrastructure and support of the Washington University DRC, as well as its nurturing and collaborative nature, are designed to foster multidisciplinary approaches across the translational spectrum to achieve progress in understanding the pathophysiology of these disorders and in developing an infrastructure for developing new treatments, cures and preventive strategies for diabetes and its complications.
|Abraham, Manjusha; Collins, Christina A; Flewelling, Scott et al. (2018) Mitochondrial inefficiency in infants born to overweight African-American mothers. Int J Obes (Lond) 42:1306-1316|
|Mikhalkova, Deana; Holman, Sujata R; Jiang, Hui et al. (2018) Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction. Obesity (Silver Spring) 26:284-290|
|Yamaguchi, Shintaro; Moseley, Anna C; Almeda-Valdes, Paloma et al. (2018) Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People. J Clin Endocrinol Metab 103:1068-1076|
|Hsu, Fong-Fu (2018) Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view. Anal Bioanal Chem 410:6387-6409|
|Chen, Yana; McCommis, Kyle S; Ferguson, Daniel et al. (2018) Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid. Endocrinology 159:609-621|
|Rusconi, B; Jiang, X; Sidhu, R et al. (2018) Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis. Sci Rep 8:10984|
|Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256|
|Zhang, Yan; Rohatgi, Nidhi; Veis, Deborah J et al. (2018) PGC1? Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation. J Bone Miner Res 33:1114-1125|
|Zhang, Xiangyu; Evans, Trent D; Jeong, Se-Jin et al. (2018) Classical and alternative roles for autophagy in lipid metabolism. Curr Opin Lipidol 29:203-211|
|Hughes, Jing W; Bao, Yicheng K; Salam, Maamoun et al. (2018) Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease. Diabetes Care :|
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