Metabolic Tissue Function Core The purpose of the Metabolic Tissue Function Core is to improve the efficiency of diabetes-related research through provision of expertise, equipment, and services that optimize the investigational capacity of Diabetes Research Center (DRC) members. The Core facilitates acquisition of high quality rodent and human islets and assists investigators in developing induced pluripotent stem cells. In addition, the Core provides services for the functional analyses of islets and other metabolic tissues relevant to the pathogenesis of diabetes and its complications. These functional studies include hormone secretion assays, assessment of ?-cell mass, quantification of metabolism, and assessment of endoplasmic reticulum stress and oxidative stress pathways. The expertise and state-of-the-art equipment provided by the Core improve the efficiency of research focused on improving the diagnosis, treatment and cure of diabetes.

Public Health Relevance

Metabolic Tissue Function Core The Metabolic Tissue Function Core provides expertise, services, and specialized equipment required for the study of pancreatic islets and other metabolic tissues. The Core thus assists DRC investigators in the pursuit of insights into the etiology and consequences of diabetes, information critical for developing new treatments for diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020579-44
Application #
10075910
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1996-12-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
44
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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