Metabolomics Core The DRC Metabolomics Core provides rigorous mass spectrometry (MS) analyses to DRC Investigators that include quantification as well as structural characterization of diabetes-related biomolecules. The Core increases efficiency and cost effectiveness by providing centralized, standardized analyses to study molecular mechanisms of the pathogenesis of diabetes, its risk factors, and its complications. A major goal of the core is to promote use of MS methods in diabetes research by efforts in training, collaboration, development, service, and dissemination. Specific objectives of the Core are: 1) to provide and maintain functional MS systems for diabetes-related studies; 2) to consult with DRC investigators on application of MS to advance their research programs; 3) to perform service-related MS analyses for diabetes investigators, such as quantifying target analytes, obtaining spectra for structural identification, and assisting with mass spectra interpretation; 4) to develop new MS methods; and 5) to provide training to students and fellows in principles and use of MS systems. The services offered by the Metabolomics Core reflect the evolving bioanalytical needs of DRC investigators, including targeted metabolomic services to broadly survey multiple metabolic pathways and quantify pathway metabolites, in addition to high-throughput, quality-controlled measurements of analytes in large sample sets from clincal studies.

Public Health Relevance

Metabolomics Core Diabetes-related research requires the ability to analyze molecules reflecting the metabolism of glucose, cholesterol, fatty acids, and other key mediators of diabetes and its complications. The DRC Metabolomics Core provides DRC members with access to equipment and expertise allowing characterization of relevant metabolic pathways and quantification of important metabolites relevant to diabetes. The goal of the Metabolomics Core is to promote use of sophisticated analytical methods in diabetes research through support of training, collaboration, development, service, and dissemination.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020579-44
Application #
10075911
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1996-12-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
44
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Wang, Songyan; Oestricker, Lauren Z; Wallendorf, Michael J et al. (2018) Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance. PLoS One 13:e0192441
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :
Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun et al. (2018) Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring) 26:683-688
Higgins, Cassandra B; Zhang, Yiming; Mayer, Allyson L et al. (2018) Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR?. JCI Insight 3:
Cahill, Alison G; Haire-Joshu, Debra; Cade, W Todd et al. (2018) Weight Control Program and Gestational Weight Gain in Disadvantaged Women with Overweight or Obesity: A Randomized Clinical Trial. Obesity (Silver Spring) 26:485-491
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 97:1284-1298.e7
Rajagopal, Rithwick; Zhang, Sheng; Wei, Xiaochao et al. (2018) Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:
Frankfater, Cheryl; Jiang, Xuntian; Hsu, Fong-Fu (2018) Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry. J Am Soc Mass Spectrom 29:1688-1699
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Rimer, Jamie M; Lee, Jiyeon; Holley, Christopher L et al. (2018) Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. J Biol Chem 293:13284-13296

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