The Pilot and Feasibility (P&F) program has funded 121 projects (including 2016) since its inception in 1978. This program has been extremely valuable and effective by providing monies for the support of diabetes- related projects. The goal of the program is to support small research projects by new investigators (who have little or no independent research support) or established investigators who are turning to diabetes research for the first time. The vast majority of the proposals are in the former category. Three new projects are normally initiated each year. After a university-wide solicitation of proposals, four individuals (two internal and two external to the institution) review each grant. The critiques of the proposal are evaluated by the P&F Review Committee (equivalent to an NIH study section), and each proposal is assigned a priority score. The proposals and priority scores are then presented to the DRTC Executive Committee (equivalent to the NIH Council) for a funding decision. Support for a second year of research is awarded when satisfactory work is completed in year one and if support for the projects has not been obtained in the interim. The success rate of this program, measured either by the number of investigators who remain involved in diabetes research, or who convert their P&F into a nationally awarded, peer-reviewed grant, is high (33% of grants funded from 2012-2016 (5 of 15). In addition, this program funds applications from a wide variety of departments within the institution. For example, faculty members from Departments of Medicine, Molecular Physiology and Biophysics, Pharmacology, Ophthalmology & Visual Sciences, Anesthesiology, Pediatrics, and Chemistry were funded over the past five years. The P&F program also provides visibility for the VDRTC within the Vanderbilt scientific community and thus makes the scientific community more aware of the VDRTC, its research efforts, and its core facilities. The importance and effectiveness of the VDRTC P&F program is underscored by the decision of the VUMC leadership to provide additional P&F funds ($100K/year) for this program in the next funding cycle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020593-40
Application #
9330514
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J1)P)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
40
Fiscal Year
2017
Total Cost
$447,226
Indirect Cost
$157,760
Name
Vanderbilt University Medical Center
Department
Type
Independent Hospitals
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Horwitz, Elad; Krogvold, Lars; Zhitomirsky, Sophia et al. (2018) ?-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes 67:2305-2318
Herrick, Mary K; Favela, Kristin M; Simerly, Richard B et al. (2018) Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice. Mol Med 24:56
Martinez 2nd, Keith A; Romano-Keeler, Joann; Zackular, Joseph P et al. (2018) Bacterial DNA is present in the fetal intestine and overlaps with that in the placenta in mice. PLoS One 13:e0197439
Perez, Katia M; Curley, Kathleen L; Slaughter, James C et al. (2018) Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism. J Clin Endocrinol Metab 103:4265-4274
Saunders, Diane C; Brissova, Marcela; Phillips, Neil et al. (2018) Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In Vitro and In Vivo Analysis. Cell Metab :
Marre, Meghan L; McGinty, John W; Chow, I-Ting et al. (2018) Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes 67:1356-1368
Wang, Feng; Katagiri, Daisuke; Li, Ke et al. (2018) Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. Magn Reson Med 80:2655-2669
Creecy, Amy; Uppuganti, Sasidhar; Unal, Mustafa et al. (2018) Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age. Bone 110:204-214
Santos Guasch, Gabriela L; Beeler, J Scott; Marshall, Clayton B et al. (2018) p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion. iScience 8:236-249

Showing the most recent 10 out of 697 publications