This proposal seeks the continuation of the University of Chicago Diabetes Research and Training Center (DRTC). The Center is a broad-based interdepartmental and inter-institutional endeavor that is centered at the University of Chicago with the participation of investigators from the Illinois Institute of Technology, Loyola Universit Chicago, Northwestern, the University of Illinois at Chicago, Rush University, Rosalind Franklin University of Medicine and Science and the Medical College of Wisconsin - Milwaukee with differing scientific backgrounds, yet sharing a common interest in diabetes and related research. The overall aim of this center is to promote new discoveries and enhance scientific progress by supporting cutting-edge basic and clinical research on the etiology of diabetes and its complications with the goal of rapidly translating research findings into novel strategies for the prevention, treatment and cure of diabetes and related conditions. To this end we propose a program to: 1. Create an intellectual and physical environment that supports important and innovative diabetes research;2. Raise awareness and interest in fundamental and clinical diabetes research in the greater Chicago area as well as nationally;3. Enhance diabetes research Education and training opportunities for patients, students, fellows, scientists and clinicians;4. Attract and Retain early stage investigators and investigators new to diabetes research;5. Provide high quality core services that leverage funding and unique expertise and serve the diabetes community locally, regionally and nationally. Connect researchers and foster interdisciplinary collaborations especially in emerging areas of research, to catalyze new ideas and scientific approaches;7. Promote the translation of scientific discoveries from the bench to bedside to community to improve public health;and 8. Participate actively in and contribute to the National Diabetes Research Center program.

Public Health Relevance

The prevalence of diabetes mellitus in the United States is reaching epidemic proportions and accounts for a significant national burden of morbidity, mortality and health care expenditures. The mission of this center is to promote new discoveries and enhance scientific progress with the goal of translating research findings into novel strategies for the prevention, treatment and cure of diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020595-37
Application #
8626376
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2018-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
37
Fiscal Year
2014
Total Cost
$1,217,712
Indirect Cost
$447,008
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Letourneau, Lisa R; Greeley, Siri Atma W (2018) Congenital Diabetes: Comprehensive Genetic Testing Allows for Improved Diagnosis and Treatment of Diabetes and Other Associated Features. Curr Diab Rep 18:46
Sanyoura, May; Philipson, Louis H; Naylor, Rochelle (2018) Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options. Curr Diab Rep 18:58
RISE Consortium (2018) Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care 41:1717-1725
Letourneau, Lisa R; Greeley, Siri Atma W (2018) Congenital forms of diabetes: the beta-cell and beyond. Curr Opin Genet Dev 50:25-34
Vierra, Nicholas C; Dickerson, Matthew T; Philipson, Louis H et al. (2018) Simultaneous Real-Time Measurement of the ?-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ?-Cell Function. Methods Mol Biol 1684:73-84
Xiao, Xiangwei; Guo, Ping; Shiota, Chiyo et al. (2018) Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. Cell Stem Cell 22:78-90.e4
Weidemann, Benjamin J; Ramsey, Kathryn Moynihan; Bass, Joseph (2018) A day in the life of chromatin: how enhancer-promoter loops shape daily behavior. Genes Dev 32:321-323
Lanning, Monica S; Carmody, David; Szczerbi?ski, ?ukasz et al. (2018) Hypoglycemia in sulfonylurea-treated KCNJ11-neonatal diabetes: Mild-moderate symptomatic episodes occur infrequently but none involving unconsciousness or seizures. Pediatr Diabetes 19:393-397
Hwang, Jessica L; Park, Soo-Young; Ye, Honggang et al. (2018) FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Diabetes 19:388-392
Harris, Anastasia G; Letourneau, Lisa R; Greeley, Siri Atma W (2018) Monogenic diabetes: the impact of making the right diagnosis. Curr Opin Pediatr 30:558-567

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