The Pilot and Feasibility Program (P&F) of the DRTC has funded 127 grants since its inception in 1977. In addition, this past cycle the P&F program funded 6 applicafions from investigators located outside the University of Chicago, both assisting their diabetes related studies, but also importantly the P&F program acts as a catalyst to bring together researchers from throughout the Chicago area. We plan to expand the program in the coming cycle to also include investigators at the Medical College of Wisconsin. The overall goal of the P&F program is to provide initial support to newly established investigators and also to bring the expertise of more established investigators from other fields into diabetes research. Proposals are sought each year from within the University of Chicago as well as from 6 other Chicago based institutions. All proposals are evaluated by an internal and external reviewer as well as by a member of the P&F Steering Committee. Priority scores and written reviews are then presented to the entire Steering Committee and funding decisions are made. A second year funding is possible for those investigators who have made significant documented progress on their proposed research. All P&F grant recipients are strongly encouraged to present their findings at the Annual Chicago Diabetes Day held at the University of Chicago. The vast majority of P&F grants recipients have remained in diabetes research, and many have received subsequent external funding from the NIH (lllustration VI). Thus, the P&F program is an integral part of promoting diabetes research throughout the greater Chicagoland area and has also greatly enhanced the visibility of the entire DRTC program at the University of Chicago.

Public Health Relevance

The University of Chicago DRTC Pilot and Feasibility Program provides funding to new and established investigators to pursue novel research directions related to the understanding of the causes and complications of diabetes. The P&F Program actively works to bring diabetes researchers together as collaborators from throughout the greater Chicagoland area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020595-37
Application #
8626380
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
2014-02-01
Project End
2018-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
37
Fiscal Year
2014
Total Cost
$395,000
Indirect Cost
$145,000
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Sun, Juan; Mao, Liqun; Yang, Hongyan et al. (2018) Critical role for the Tsc1-mTORC1 pathway in ?-cell mass in Pdx1-deficient mice. J Endocrinol 238:151-163
Khan, Md Wasim; Ding, Xianzhong; Cotler, Scott J et al. (2018) Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans. J Histochem Cytochem 66:385-392
Sanyoura, May; Jacobsen, Laura; Carmody, David et al. (2018) Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA. J Clin Endocrinol Metab 103:35-45
Palygin, Oleg; Ilatovskaya, Daria V; Levchenko, Vladislav et al. (2018) Nitric oxide production by glomerular podocytes. Nitric Oxide 72:24-31
Letourneau, Lisa R; Greeley, Siri Atma W (2018) Congenital Diabetes: Comprehensive Genetic Testing Allows for Improved Diagnosis and Treatment of Diabetes and Other Associated Features. Curr Diab Rep 18:46
Sanyoura, May; Philipson, Louis H; Naylor, Rochelle (2018) Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options. Curr Diab Rep 18:58
RISE Consortium (2018) Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care 41:1717-1725
Letourneau, Lisa R; Greeley, Siri Atma W (2018) Congenital forms of diabetes: the beta-cell and beyond. Curr Opin Genet Dev 50:25-34
Vierra, Nicholas C; Dickerson, Matthew T; Philipson, Louis H et al. (2018) Simultaneous Real-Time Measurement of the ?-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ?-Cell Function. Methods Mol Biol 1684:73-84
Xiao, Xiangwei; Guo, Ping; Shiota, Chiyo et al. (2018) Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. Cell Stem Cell 22:78-90.e4

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