This proposal seeks the continuation of the University of Chicago Diabetes Research and Training Center (DRTC). The Center is a broad-based interdepartmental and inter-institutional endeavor that is centered at the University of Chicago with the participation of investigators from the Illinois Institute of Technology, Loyola Universit Chicago, Northwestern, the University of Illinois at Chicago, Rush University, Rosalind Franklin University of Medicine and Science and the Medical College of Wisconsin - Milwaukee with differing scientific backgrounds, yet sharing a common interest in diabetes and related research. The overall aim of this center is to promote new discoveries and enhance scientific progress by supporting cutting-edge basic and clinical research on the etiology of diabetes and its complications with the goal of rapidly translating research findings into novel strategies for the prevention, treatment and cure of diabetes and related conditions. To this end we propose a program to: 1. Create an intellectual and physical environment that supports important and innovative diabetes research; 2. Raise awareness and interest in fundamental and clinical diabetes research in the greater Chicago area as well as nationally; 3. Enhance diabetes research Education and training opportunities for patients, students, fellows, scientists and clinicians; 4. Attract and Retain early stage investigators and investigators new to diabetes research; 5. Provide high quality core services that leverage funding and unique expertise and serve the diabetes community locally, regionally and nationally. Connect researchers and foster interdisciplinary collaborations especially in emerging areas of research, to catalyze new ideas and scientific approaches; 7. Promote the translation of scientific discoveries from the bench to bedside to community to improve public health; and 8. Participate actively in and contribute to the National Diabetes Research Center program.

Public Health Relevance

The prevalence of diabetes mellitus in the United States is reaching epidemic proportions and accounts for a significant national burden of morbidity, mortality and health care expenditures. The mission of this center is to promote new discoveries and enhance scientific progress with the goal of translating research findings into novel strategies for the prevention, treatment and cure of diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
4P30DK020595-39
Application #
8996156
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2018-01-31
Budget Start
2016-02-01
Budget End
2017-01-31
Support Year
39
Fiscal Year
2016
Total Cost
$1,217,712
Indirect Cost
$447,008
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Reneau, James; Goldblatt, Matthew; Gould, Jon et al. (2018) Effect of adiposity on tissue-specific adiponectin secretion. PLoS One 13:e0198889
Flannick, Jason (see original citation for additional authors) (2018) Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data 5:180002
RISE Consortium (2018) Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care 41:1707-1716
Lemelman, Michelle Blanco; Letourneau, Lisa; Greeley, Siri Atma W (2018) Neonatal Diabetes Mellitus: An Update on Diagnosis and Management. Clin Perinatol 45:41-59
Ilatovskaya, Daria V; Blass, Gregory; Palygin, Oleg et al. (2018) A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. J Am Soc Nephrol 29:1917-1927
Markussen, Lasse K; Winther, Sally; Wicksteed, Barton et al. (2018) GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep 8:3469
Boland, Brandon B; Brown Jr, Charles; Alarcon, Cristina et al. (2018) ?-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats. Endocrinology 159:895-906
Bonini, Marcelo G; Sargis, Robert M (2018) Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise. Curr Opin Toxicol 7:52-59
Bergeron, Valérie; Ghislain, Julien; Vivot, Kevin et al. (2018) Deletion of Protein Kinase D1 in Pancreatic ?-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Diabetes 67:71-77
Chen, Han; Cade, Brian E; Gleason, Kevin J et al. (2018) Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol 58:391-401

Showing the most recent 10 out of 298 publications