The overarching mission of the MB/MG Core is assist investigators seeking to discover the molecular basesunderlying obesity and its comorbidities. To achieve this mission, the Core performs studies in humans androdents to identify mutations in candidate genes as well as rodent studies to define the functions ofcandidate genes by genetic manipulations using transgenic methodologies, the MB/MG Core makesavailable to biomedical investigators a wide range of methodologies and reagents relevant to understandingme molecular physiology of obesity and energy metabolism in animals and humans. This core appliesmolecular genetic and molecular biological techniques to the mapping, cloning and functionalcharacterization of genes related to obesity and its comorbidities. The services of this Core are available toinvestigators new to obesity research, as well as to investigators working on obesity-related projects that canbe enriched and extended by the use of the expertise and facilities of this core. This Core operates in 2collaborating sites: Columbia University (R. Leibel) and AECOM (S. Chua). In general, techniques andservices related to studies in humans are located at the former, and those related to rodents at tne fatter.However, this distinction is not rigid, and there is a lot of crossover between the sites. Services fndude a fullrange of capabilities in DNA and RNA isolation, sequencing, manipulation and quantification; experimentaldesign and execution of gene/QTL-mapping studies in rodents and humans; maintenance of novel mousegenetic models of obesity; and design and execution of mouse transgenesis experiments.
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