The New York Obesity Nutrition Research Center (NYONRC) has as its primary aim to convene and support - by its Core Services, Pilot & Feasibility and Enrichment programs - funded investigators at Columbia University and the Albert Einstein College of Medicine studying obesity. The themes for this Center include: the etiology, pathophysiology and complications of obesity; treatment strategies; the physiology of weight regulation; development of new tools and strategies for the study of nutrition and obesity; and the training and development of scientists to study nutrition and obesity. A particular strength of the NYONRC, by design, is an explicit commitment to the promotion of multidisciplinary research that integrates basic observations relating to nutritional, metabolic an behavioral biology, with the application of these insights to clinical approaches to the prevention and treatment of obesity. The size and breadth of our base has provided a strong basis for collaborations and productivity. During the current cycle, the research base has grown substantially from 75 to 109 funded members. In 2014, NYONRC members were PIs on 155 obesity-related NIH grants totaling $55,939,716 in direct costs ($19,032,744 NIDDK) and 55 foundations and pharmaceutical entities supported obesity-related grants totaling $9,595,751. Furthermore, members are PIs of ten NIH training grants, three P01 program projects, the CTSA at Columbia, and mentors of ten K series and three F31 graduate awards. These efforts are supported by our three Biomedical Research Cores: Human Phenotyping, Animal Phenotyping and Molecular Biology/Molecular Genetics. Since the last submission, the Cores have provided ~25,000 services to 91 members, including ~9000 services now provided by the Human Phenotyping Core, 14,000 services from the Animal Phenotyping Core and >3000 service requests involving more than 100,000 samples by the Molecular Genetics/Molecular Biology Core. . The research base is also supported by a highly successful Pilot & Feasiblity Program - subsidized by the sponsoring institutions - that awarded $820,000 to 10 investigators since the last submission. The NYONRC is a dynamic enterprise that has strong institutional support permitting it to evolve and thrive as it fosters novel and collaborative science in the study of obesity.

Public Health Relevance

The NYONRC, the oldest NIH obesity research center, operates in support of $65M per year of peer-reviewed obesity-related research. Through closely integrated, outstanding core facilities, pilot projects, enrichment and clinical activities, the center has made major contributions to basic understanding and applied approaches to the problem of obesity. Our goal remains to expand the knowledge base relating to the causes, complications and treatment of obesity

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
Program Officer
Evans, Mary
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Columbia University (N.Y.)
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Espeland, Mark A; Luchsinger, Jose A; Neiberg, Rebecca H et al. (2018) Long Term Effect of Intensive Lifestyle Intervention on Cerebral Blood Flow. J Am Geriatr Soc 66:120-126
Liu, Shunmei; Marcelin, Genevieve; Blouet, Clemence et al. (2018) A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab 8:37-50
Cheng, X; Zhang, Y; Wang, C et al. (2018) The optimal anatomic site for a single slice to estimate the total volume of visceral adipose tissue by using the quantitative computed tomography (QCT) in Chinese population. Eur J Clin Nutr 72:1567-1575
Fang, Hongjuan; Berg, Elizabeth; Cheng, Xiaoguang et al. (2018) How to best assess abdominal obesity. Curr Opin Clin Nutr Metab Care 21:360-365
Stratigopoulos, George; De Rosa, Maria Caterina; LeDuc, Charles A et al. (2018) DMSO increases efficiency of genome editing at two non-coding loci. PLoS One 13:e0198637
Schwartz, Gary J (2018) Roles for gut vagal sensory signals in determining energy availability and energy expenditure. Brain Res 1693:151-153
Jeong, Jae Hoon; Lee, Dong Kun; Liu, Shun-Mei et al. (2018) Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol 16:e2004399
Carli, Jayne F Martin; LeDuc, Charles A; Zhang, Yiying et al. (2018) The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function. FASEB J 32:3946-3956
Gallagher, Dympna; Rosenn, Barak; Toro-Ramos, Tatiana et al. (2018) Greater Neonatal Fat-Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain. Obesity (Silver Spring) 26:578-587
Rosenbaum, Michael; Goldsmith, Rochelle L; Haddad, Fadia et al. (2018) Triiodothyronine and leptin repletion in humans similarly reverse weight-loss induced changes in skeletal muscle. Am J Physiol Endocrinol Metab :

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