Abstract

A large number of diabetes-related research investigators at the University of Massachusetts Medical Center depend upon morphologic techniques to analyze their experimental models. The Morphology Core Facility satisfies the need of investigators by providing service in this area. The core provides routine histology and identification of tissue and cellular antigens utilizing immunofluorescence and immunoperoxidase techniques. The Core Director and research associate actively consult with investigators on experimental design and will train individuals in adopting these techniques in their own laboratories. The Core Director provides interpretative consultation to individual laboratories. This core enhances the productivity of Diabetes research by a) providing services not available in individual laboratories, b) allowing investigators to focus on their own projects without the need to develop their own histology and immunoperoxidase functions and 3) by encouraging interactions between investigators who share the resources of this core facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK032520-26
Application #
7807969
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
2012-03-31
Budget Start
2009-04-01
Budget End
2013-03-31
Support Year
26
Fiscal Year
2009
Total Cost
$187,951
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Type
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Desai, Paurav B; San Agustin, Jovenal T; Stuck, Michael W et al. (2018) Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev 151:10-17
Ly, Socheata; Navaroli, Deanna M; Didiot, Marie-Cécile et al. (2017) Visualization of self-delivering hydrophobically modified siRNA cellular internalization. Nucleic Acids Res 45:15-25
Wang, Feng; McCannell, Kurtis N; Boškovi?, Ana et al. (2017) Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs. Cell Rep 21:3691-3699
Watkin, Levi B; Mishra, Rabinarayan; Gil, Anna et al. (2017) Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion. J Allergy Clin Immunol 140:1206-1210
LeBlanc, Scott E; Wu, Qiong; Lamba, Pallavi et al. (2016) Promoter-enhancer looping at the PPAR?2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res 44:5133-47
Wang, Feng; Shin, JongDae; Shea, Jeremy M et al. (2016) Regulation of X-linked gene expression during early mouse development by Rlim. Elife 5:
Kincaid, Eleanor Z; Murata, Shigeo; Tanaka, Keiji et al. (2016) Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells. Nat Immunol 17:938-45
Townsley, E; O'Connor, G; Cosgrove, C et al. (2016) Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells. Clin Exp Immunol 183:419-30
Wyss, Lena; Stadinski, Brian D; King, Carolyn G et al. (2016) Affinity for self antigen selects Treg cells with distinct functional properties. Nat Immunol 17:1093-101
Delong, Thomas; Wiles, Timothy A; Baker, Rocky L et al. (2016) Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science 351:711-4

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