Abstract

The Proteomics Core aims to provide HDDC investigators with access to state of the arttechnologies in mass spectrometry, microscale capillary high performance liquid chromatography, andrelated proteomics technologies required for advanced studies in cell and molecular biology of theintestinal epjthelium. Dr. Hanno Steen PhD, (Assistant Professor of Pathology, HMS) directs the Coreand is responsible for all core activities. The Core is the most advanced proteomics unit on the HMScampus.The significance of the research supported by the Proteomics Core D is emphasized by therapid advances in technology for the unbiased and efficient identification of proteins in biologicalsamples that has allowed new approaches to studies on the intestinal mucosa.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK034854-21A1
Application #
7001989
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Project Start
2005-12-01
Project End
2010-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
21
Fiscal Year
2006
Total Cost
$50,676
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Hong, Shangyu; Song, Wei; Zushin, Peter-James H et al. (2018) Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab 12:25-38
Aden, Konrad; Tran, Florian; Ito, Go et al. (2018) ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. J Exp Med 215:2868-2886
Smillie, Christopher S; Sauk, Jenny; Gevers, Dirk et al. (2018) Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation. Cell Host Microbe 23:229-240.e5
Sallis, Benjamin F; Acar, Utkucan; Hawthorne, Kelsey et al. (2018) A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions. Front Immunol 9:2059
Li, Katherine; Strauss, Richard; Ouahed, Jodie et al. (2018) Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. J Pediatr Gastroenterol Nutr 67:45-52
Li, Yang; Fu, Tian-Min; Lu, Alvin et al. (2018) Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A 115:10845-10852
Morris, Hayley T; Fort, Loic; Spence, Heather J et al. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. J Pathol 245:337-348
Panchal, Pratik; Budree, Shrish; Scheeler, Alex et al. (2018) Correction to: Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future. Curr Gastroenterol Rep 20:28
O'Connell, Amy E; Zhou, Fanny; Shah, Manasvi S et al. (2018) Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet 103:131-137
Allegretti, J R; Allegretti, A S; Phelps, E et al. (2018) Asymptomatic Clostridium difficile carriage rate post-fecal microbiota transplant is low: a prospective clinical and stool assessment. Clin Microbiol Infect 24:780.e1-780.e3

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