Introduction to Center and Core Missions The Harvard Digestive Disease Center is focused on the cell biology and function of epithelial cells of the alimentary tract, liver, and pancreas; and how epithelial biology manifests itself in mucosal immunity and allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract The Center aims to facilitate multidisciplinary research in this field by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in the Longwood Medical Area. We also aim to recruit new and established investigators into the fields of gastrointestinal biology. Our overarching mission is to foster better basic and translational science in fields related to digestive diseases by: Connecting people, creating opportunity, and ^extending resources. Shared intellectual and scientific resources to enhance this effort and the productivity of our research base are provided by four service Cores and an Administrative Core (see Figure 1-CoreC at the end of this section). Each Core provides the following general resources to the HDDC: Core Services Materials and Reagents Instrumentation and Equipment Expertise, Protocols, and Training Core-development research

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034854-30
Application #
8786545
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2014-12-01
Budget End
2015-11-30
Support Year
30
Fiscal Year
2015
Total Cost
$130,617
Indirect Cost
$48,298
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
McSweeney, Maireade E; Kerr, Jessica; Amirault, Janine et al. (2018) Preoperative Evaluation Is Not Predictive of Transpyloric Feeding Conversion in Gastrostomy-dependent Pediatric Patients. J Pediatr Gastroenterol Nutr 66:887-892
Thiagarajah, Jay R; Kamin, Daniel S; Acra, Sari et al. (2018) Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology 154:2045-2059.e6
Masuyer, Geoffrey; Zhang, Sicai; Barkho, Sulyman et al. (2018) Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity. Sci Rep 8:4518
Xenakis, Jason J; Howard, Emily D; Smith, Kalmia M et al. (2018) Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils. Immunology 154:298-308
Desai, Anal; Alves-Bezerra, Michele; Li, Yingxia et al. (2018) Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1. J Lipid Res 59:368-379
Richmond, Camilla A; Rickner, Hannah; Shah, Manasvi S et al. (2018) JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports 10:17-26
Rankin, Carl Robert; Theodorou, Evangelos; Man Law, Ivy Ka et al. (2018) Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 315:G722-G733
Garcia-Castillo, Maria Daniela; Lencer, Wayne I; Chinnapen, Daniel J-F (2018) Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells. Bio Protoc 8:
Richardson, Gavin David; Sage, Andrew; Bennaceur, Karim et al. (2018) Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol 38:1283-1296
Hong, Shangyu; Song, Wei; Zushin, Peter-James H et al. (2018) Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab 12:25-38

Showing the most recent 10 out of 869 publications