The overarching goal of the HDDC is to support and accelerate progress in understanding the fundamental mechanisms underlying digestive health and disease. The mission of the Administrative Core (Core A) is to provide leadership, administrative support, oversight, and coordination of all HDDC activities so as to achieve the Center?s goals.
Specific Aims of the Administrative Core are: 1: To manage the HDDC membership and recruitment of new members to digestive disease research. 2: To oversee the Biomedical Cores to assure that they are equipped and organized to meet members? scientific needs, and to monitor Core use. 3: To manage all supporting Center programs: the Pilot Feasibility Grant Program, the Clinical Translational Research Program, and the Enrichment Program. 4: To manage Center finances and all administrative interactions with the four major Harvard institutions supporting the HDDC: Harvard Medical School (HMS), Boston Children?s Hospital (BCH), Brigham and Women?s Hospital (BWH), and Beth Israel Deaconess Medical Center. (BIDMC). 5: To manage communications among the Membership, the Cores, and with the broader scientific community through maintenance of the HDDC web site and distribution of announcements and information via our broad email network. 6: To provide timely reports to the NIDDK and manage interactions with other NIH-funded Scientific Centers and other Core facilities located on or off the HMS Longwood campus. The Center Director Wayne Lencer MD at BCH, and Associate Director Richard Blumberg MD at BWH, lead the Administrative Core with assistance from an Executive Committee that includes all Core Directors and Theme Leaders. Guidance is also provided by an Internal Advisory Committee representing the four major HDDC-affiliated Institutions (BCH, BWH, HMS and BIDMC) and an External Advisory Board that includes national leaders in digestive disease research consistent with the Research Themes of the HDDC.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZDK1)
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Boston Children's Hospital
United States
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Dumontet, Typhanie; Sahut-Barnola, Isabelle; Septier, Amandine et al. (2018) PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight 3:
Brown, Jonathan D; Feldman, Zachary B; Doherty, Sean P et al. (2018) BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A 115:2144-2149
Syed, Ismail; Lee, Jennifer; Moraes-Vieira, Pedro M et al. (2018) Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab 27:419-427.e4
Jirapinyo, Pichamol; Thompson, Andrew C; Kröner, Paul T et al. (2018) Metabolic Effect of Foregut Exclusion Demonstrated by the Impact of Gastrogastric Fistula on Recurrence of Diabetes. J Am Coll Surg 226:259-266.e1
Khandekar, Melin J; Banks, Alexander S; Laznik-Bogoslavski, Dina et al. (2018) Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A 115:561-566
Schulman, Allison R; Kumar, Nitin; Thompson, Christopher C (2018) Transoral outlet reduction: a comparison of purse-string with interrupted stitch technique. Gastrointest Endosc 87:1222-1228
Hagen, Susan J; Ang, Lay-Hong; Zheng, Yi et al. (2018) Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach. Gastroenterology 155:1852-1867
Schulman, Allison R; Thompson, Christopher C (2018) Endoscopic reconstruction of Roux-en-Y gastric bypass with placement of gastrojejunal and remnant-jejunal lumen-apposing metal stents. Gastrointest Endosc 87:890-891
Cox, Andrew G; Tsomides, Allison; Yimlamai, Dean et al. (2018) Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J 37:
Allegretti, Jessica R; Kassam, Zain; Chan, Walter W (2018) Small Intestinal Bacterial Overgrowth: Should Screening Be Included in the Pre-fecal Microbiota Transplantation Evaluation? Dig Dis Sci 63:193-197

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