The overarching goal of the HDDC is to facilitate the discovery of basic mechanisms underlying digestive health and disease, and to encourage the translation of these basic discoveries to improvement in patient care. The Clinical and Translational Program (Clinical Component) of the HDDC is designed to support basic science by providing human materials to HDDC members who are conducting basic and translational laboratory research, and also to support the specialized needs of our collaborating ?Clinical Associates.? Our strategy is to facilitate and support collaborations between basic, translational, and clinical researchers, and to leverage resources currently in place at CHB and BWH, by ?buying in? to the BCH Bio-Repository & Harvard IBD Data Registry, the BWH Inflammatory Bowel Disease Tissue Repository (BrITR), and BCH/BWH Biostatistics Resources.
The Specific Aims of the HDDC Clinical and Translational Research Program are: 1. To forge collaborations between HDDC Clinical Associates and HDDC Members, thus assuring availability of fresh and stored human samples for basic and translational research, and guiding HDDC basic research advances toward potential clinical applications. 2. To support a well-organized infrastructure for acquisition and storage of clinical samples (with relevant clinical metadata) as a long-term resource for current and future studies on gastrointestinal and liver diseases and normal human digestive function. 3. To provide professional support in biostatistics and study design to HDDC members and Clinical Associates for effective design of clinical studies and appropriate analysis and interpretation of data. The Clinical and Translational Program is directed by Scott B Snapper, MD, PhD, Director of the Center for IBD within the GI Division at CHB and Director of IBD Research at BWH. The Program has established clear guidelines for prioritization of resources for HDDC members and Clinical Associates, including access to fresh or stored human samples and availability of biostatistical support personnel. The Program is heavily subsidized by non-HDDC grant support and institutional resources from the Divisions of GI at BCH and BWH.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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Boston Children's Hospital
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Kasendra, Magdalena; Tovaglieri, Alessio; Sontheimer-Phelps, Alexandra et al. (2018) Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep 8:2871
Wilen, Craig B; Lee, Sanghyun; Hsieh, Leon L et al. (2018) Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science 360:204-208
Rodriguez-Fraticelli, Alejo E; Wolock, Samuel L; Weinreb, Caleb S et al. (2018) Clonal analysis of lineage fate in native haematopoiesis. Nature 553:212-216
Franz, Kate M; Neidermyer, William J; Tan, Yee-Joo et al. (2018) STING-dependent translation inhibition restricts RNA virus replication. Proc Natl Acad Sci U S A 115:E2058-E2067
Brown, Jonathan D; Feldman, Zachary B; Doherty, Sean P et al. (2018) BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A 115:2144-2149
Dumontet, Typhanie; Sahut-Barnola, Isabelle; Septier, Amandine et al. (2018) PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight 3:
Jirapinyo, Pichamol; Thompson, Andrew C; Kr├Âner, Paul T et al. (2018) Metabolic Effect of Foregut Exclusion Demonstrated by the Impact of Gastrogastric Fistula on Recurrence of Diabetes. J Am Coll Surg 226:259-266.e1
Syed, Ismail; Lee, Jennifer; Moraes-Vieira, Pedro M et al. (2018) Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab 27:419-427.e4
Schulman, Allison R; Kumar, Nitin; Thompson, Christopher C (2018) Transoral outlet reduction: a comparison of purse-string with interrupted stitch technique. Gastrointest Endosc 87:1222-1228
Khandekar, Melin J; Banks, Alexander S; Laznik-Bogoslavski, Dina et al. (2018) Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A 115:561-566

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