Abstract

application) The specific aims of the Gnotobiotic Core are 1. to provide germ-free or gnotobiotic rodents and conventional controls to center members as first priority, but to also provide these unique resources to investigators around the world; 2. to establish new genetic stocks and strains of rodents in an axenic, gnotobiotic or conventional status as required by research projects; 3. to provide technical assistance and isolators to maintain axenic and gnotobiotic rodent models; 4. to provide technical assistance to maintain control animals free of disease and inoculated with various gut microbiotas;5. to provide specific pathogen free conditions for maintaining production of a variety of genetically engineered rodents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034987-16
Application #
6410307
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
16
Fiscal Year
2001
Total Cost
$166,667
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Pollard, Katharine L; Campbell, Christina; Squires, Megan et al. (2018) Seasonal Association of Pediatric Functional Abdominal Pain Disorders and Anxiety. J Pediatr Gastroenterol Nutr 67:18-22
Weiser, Matthew; Simon, Jeremy M; Kochar, Bharati et al. (2018) Molecular classification of Crohn's disease reveals two clinically relevant subtypes. Gut 67:36-42
Kaelberer, Melanie Maya; Buchanan, Kelly L; Klein, Marguerita E et al. (2018) A gut-brain neural circuit for nutrient sensory transduction. Science 361:
Ellermann, Melissa; Sartor, R Balfour (2018) Intestinal bacterial biofilms modulate mucosal immune responses. J Immunol Sci 2:13-18
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Kochar, Bharati; Barnes, Edward L; Long, Millie D et al. (2018) Depression Is Associated With More Aggressive Inflammatory Bowel Disease. Am J Gastroenterol 113:80-85
Dong, Jing; Buas, Matthew F; Gharahkhani, Puya et al. (2018) Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants. Gastroenterology 154:1273-1281.e3
Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Carlson, Alexander L; Xia, Kai; Azcarate-Peril, M Andrea et al. (2018) Infant Gut Microbiome Associated With Cognitive Development. Biol Psychiatry 83:148-159
Azcarate-Peril, M Andrea; Butz, Natasha; Cadenas, Maria Belen et al. (2018) An Attenuated Salmonella enterica Serovar Typhimurium Strain and Galacto-Oligosaccharides Accelerate Clearance of Salmonella Infections in Poultry through Modifications to the Gut Microbiome. Appl Environ Microbiol 84:

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