Abstract

application) The specific aims of the Gnotobiotic Core are 1. to provide germ-free or gnotobiotic rodents and conventional controls to center members as first priority, but to also provide these unique resources to investigators around the world; 2. to establish new genetic stocks and strains of rodents in an axenic, gnotobiotic or conventional status as required by research projects; 3. to provide technical assistance and isolators to maintain axenic and gnotobiotic rodent models; 4. to provide technical assistance to maintain control animals free of disease and inoculated with various gut microbiotas;5. to provide specific pathogen free conditions for maintaining production of a variety of genetically engineered rodents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034987-16
Application #
6410307
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
16
Fiscal Year
2001
Total Cost
$166,667
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Gracz, Adam D; Samsa, Leigh Ann; Fordham, Matthew J et al. (2018) Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates. Gastroenterology 155:1508-1523.e10
Keith, Benjamin P; Barrow, Jasmine B; Toyonaga, Takahiko et al. (2018) Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. JCI Insight 3:
Evon, Donna M; Stewart, Paul W; Amador, Jipcy et al. (2018) A comprehensive assessment of patient reported symptom burden, medical comorbidities, and functional well being in patients initiating direct acting antiviral therapy for chronic hepatitis C: Results from a large US multi-center observational study. PLoS One 13:e0196908
Mackie, Duncan I; Al Mutairi, Fuad; Davis, Reema B et al. (2018) hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. J Exp Med 215:2339-2353
Efird, William M; Fletcher, Alex G; Draeger, Reid W et al. (2018) Deferoxamine-Soaked Suture Improves Angiogenesis and Repair Potential After Acute Injury of the Chicken Achilles Tendon. Orthop J Sports Med 6:2325967118802792
Smith, Nicholas R; Swain, John R; Davies, Paige S et al. (2018) Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations. Cell Mol Gastroenterol Hepatol 6:79-96
Egberg, Matthew D; Mitchell, Paul D; Galanko, Joseph A et al. (2018) Effectiveness of oral iron supplementation in treatment of anemia associated with pediatric ulcerative colitis flare. Am J Hematol 93:E404-E406
Jacob, Noam; Jacobs, Jonathan P; Kumagai, Kotaro et al. (2018) Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol 11:1466-1476
Peery, Anne F; Keku, Temitope O; Addamo, Cassandra et al. (2018) Colonic Diverticula Are Not Associated With Mucosal Inflammation or Chronic Gastrointestinal Symptoms. Clin Gastroenterol Hepatol 16:884-891.e1
Kochar, Bharati; Barnes, Edward L; Herfarth, Hans H et al. (2018) Asians have more perianal Crohn disease and ocular manifestations compared with white Americans. Inflamm Intest Dis 2:147-153

Showing the most recent 10 out of 944 publications