Abstract

application) This core in the previous funded period was the Immunoassay Core. The objectives of this core is to provide the investigators 1. with convenient and accurate RIA, ELISA, or Western blot analyses; 2. the opportunity to generate new antibodies or immunoassays that are not commercially available; 3. the option of rigorously evaluating the specificity of any immunoassay with a battery of supplementary biochemical analyses, including HPLC characterization and or Western blotting of antigen-containing extracts, and 4. the capability to use antigenic determinants to generate pure populations of cells for direct analysis, or for further study in conjunction with the tissue culture capabilities of the Advanced Cell Technologies (ACT) core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034987-16
Application #
6410309
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
16
Fiscal Year
2001
Total Cost
$166,667
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Dong, Jing; Levine, David M; Buas, Matthew F et al. (2018) Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. Clin Gastroenterol Hepatol 16:1598-1606.e4
Truax, Agnieszka D; Chen, Liang; Tam, Jason W et al. (2018) The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host Microbe 24:364-378.e6
Palacios, Michelle; Miner, Taryn A; Frederick, Daniel R et al. (2018) Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. MBio 9:
Williamson, Ian A; Arnold, Jason W; Samsa, Leigh Ann et al. (2018) A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. Cell Mol Gastroenterol Hepatol 6:301-319
Zhang, Cun-Jin; Wang, Chenhui; Jiang, Meiling et al. (2018) Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun 9:2745
Evon, Donna M; Golin, Carol E; Ruffin, Rachel et al. (2018) Novel patient-reported outcomes (PROs) used in a pilot and feasibility study of a Cognitive Behavioral Coping Skills (CBCS) group intervention for patients with chronic hepatitis C. Pilot Feasibility Stud 4:92
Busch, Evan L; Don, Prabhani Kuruppumullage; Chu, Haitao et al. (2018) Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors. BMC Cancer 18:82
Herfarth, Hans; Barnes, Edward L; Valentine, John F et al. (2018) Methotrexate Is Not Superior to Placebo in Maintaining Steroid-Free Response or Remission in Ulcerative Colitis. Gastroenterology 155:1098-1108.e9
Koutlas, N T; Eluri, S; Rusin, S et al. (2018) Impact of smoking, alcohol consumption, and NSAID use on risk for and phenotypes of eosinophilic esophagitis. Dis Esophagus 31:1-7
Reese, Aspen T; Cho, Eugenia H; Klitzman, Bruce et al. (2018) Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. Elife 7:

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