? MORPHOLOGY CORE The Morphology Core Facility provides instrumentation and technical expertise for the preparation, acquisition and analysis of images of cells and tissues at both the light and electron microscopic level. Given the cost of such instrumentation and the high level of technical expertise required to perform these investigational techniques, this Core was established to ensure the availability of these techniques for Center members. In recognition of the broad usefulness of this Core facility, the School of Medicine has partnered with the Liver Center by making ongoing, major investments to ensure that the facility remains state-of-the-art. The Morphology Core offers the following specific activities and services, plus associated training and technical support: (1) confocal microscopy, (2) multiphoton microscopy, (3) super-resolution microscopy, (4) swept field microscopy, (5) light sheet microscopy, (6) electron microscopy, (7) image analysis, and (8) other microscopy tools, including widefield and brightfield microscopy and cryo-sectioning. More than two-thirds of the members of the Liver Center used this core facility and the core was used in over one hundred forty publications during the current award period, reflecting the continued usefulness and importance of this resource for the mission of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK034989-36A1
Application #
10048270
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1997-09-30
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
36
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Sachar, Hamita; Pichetshote, Nipaporn; Nandigam, Kavitha et al. (2018) Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointest Endosc 87:1297-1303
Bhutta, A Q; Garcia-Tsao, G; Reddy, K R et al. (2018) Beta-blockers in hospitalised patients with cirrhosis and ascites: mortality and factors determining discontinuation and reinitiation. Aliment Pharmacol Ther 47:78-85
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Hollister, Kristin; Kusumanchi, Praveen; Ross, Ruth Ann et al. (2018) Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis. Liver Res 2:52-59
Garcia-Tsao, Guadalupe (2018) Management of Acute Variceal Hemorrhage as a Model of Individualized Care for Patients With Cirrhosis. Clin Gastroenterol Hepatol 16:24-26
Fonseca, Matheus de Castro; França, Andressa; Florentino, Rodrigo Machado et al. (2018) Cholesterol-enriched membrane microdomains are needed for insulin signaling and proliferation in hepatic cells. Am J Physiol Gastrointest Liver Physiol 315:G80-G94
Chang, Binxia; Hao, Shuli; Zhang, Longyu et al. (2018) Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. Am J Med Sci 356:10-14
Sullivan, Rebecca; Abraham, Alice; Simpson, Christine et al. (2018) Three-Month Randomized Clinical Trial of Nasal Calcitonin in Adults with X-linked Hypophosphatemia. Calcif Tissue Int 102:666-670
Ouyang, Xinshou; Han, Sheng-Na; Zhang, Ji-Yuan et al. (2018) Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1? Transactivation in Steatohepatitis. Cell Metab 27:339-350.e3
Chen, Yonglin; Ouyang, Xinshou; Hoque, Rafaz et al. (2018) ?-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway. J Hepatol 69:687-696

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