Abstract

The objective of the Joslin Genomics Core Facility is to provide support to Joslin and a certain number ofexternal investigators for analysis of gene expression, by providing equipment, expertise, and services innucleic acid analysis that would be too specialized or costly for individual laboratories to performindependently. Core services include both high-density oligonucleotide array analysis, using the Affymetrixplatform, and real-time quantitative fluorescent PCR analysis. The core also provides preliminary genomicanalysis, software support, and technical advice regarding experimental design and sample preparation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK036836-21
Application #
7284668
Study Section
Special Emphasis Panel (ZDK1-GRB-N (J1))
Project Start
2007-04-01
Project End
2012-03-31
Budget Start
2007-06-01
Budget End
2008-03-31
Support Year
21
Fiscal Year
2007
Total Cost
$157,510
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Srinivasan, Shylaja; Kaur, Varinderpal; Chamarthi, Bindu et al. (2018) TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care 41:554-561
Goldford, Joshua E; Lu, Nanxi; Baji?, Djordje et al. (2018) Emergent simplicity in microbial community assembly. Science 361:469-474
Soto, Marion; Orliaguet, Lucie; Reyzer, Michelle L et al. (2018) Pyruvate induces torpor in obese mice. Proc Natl Acad Sci U S A 115:810-815
Karst, Sonja G; Lammer, Jan; Radwan, Salma H et al. (2018) Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. Int J Endocrinol 2018:7492946
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Kim, Youngjo; Bayona, Princess Wendy; Kim, Miri et al. (2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol 9:696
Aguayo-Mazzucato, Cristina; Bonner-Weir, Susan (2018) Pancreatic ? Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab 27:57-67
Mulla, Christopher M; Middelbeek, Roeland J W; Patti, Mary-Elizabeth (2018) Mechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci 1411:53-64
Skupien, Jan; Smiles, Adam M; Valo, Erkka et al. (2018) Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy. Diabetes Care :
Laffel, L (2018) Lost in transition: finding a path forward for young adults with Type 1 diabetes. Diabet Med 35:1061-1062

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