Abstract

The objective of the Joslin Genomics Core Facility is to provide support to Joslin and a certain number ofexternal investigators for analysis of gene expression, by providing equipment, expertise, and services innucleic acid analysis that would be too specialized or costly for individual laboratories to performindependently. Core services include both high-density oligonucleotide array analysis, using the Affymetrixplatform, and real-time quantitative fluorescent PCR analysis. The core also provides preliminary genomicanalysis, software support, and technical advice regarding experimental design and sample preparation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK036836-21
Application #
7284668
Study Section
Special Emphasis Panel (ZDK1-GRB-N (J1))
Project Start
2007-04-01
Project End
2012-03-31
Budget Start
2007-06-01
Budget End
2008-03-31
Support Year
21
Fiscal Year
2007
Total Cost
$157,510
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Kim, Youngjo; Bayona, Princess Wendy; Kim, Miri et al. (2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol 9:696
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Aguayo-Mazzucato, Cristina; Bonner-Weir, Susan (2018) Pancreatic ? Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab 27:57-67
Mulla, Christopher M; Middelbeek, Roeland J W; Patti, Mary-Elizabeth (2018) Mechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci 1411:53-64
Laffel, L (2018) Lost in transition: finding a path forward for young adults with Type 1 diabetes. Diabet Med 35:1061-1062
Skupien, Jan; Smiles, Adam M; Valo, Erkka et al. (2018) Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy. Diabetes Care :
Bauman, Viviana; Sturkey, Adaya C; Sherafat-Kazemzadeh, Rosa et al. (2018) Factitious hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes 19:823-831
Rao, Tata Nageswara; Gupta, Manoj K; Softic, Samir et al. (2018) Attenuation of PKC? enhances metabolic activity and promotes expansion of blood progenitors. EMBO J 37:
Park, Kyoungmin; Li, Qian; Evcimen, Net Da? et al. (2018) Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arterioscler Thromb Vasc Biol 38:92-101
Stanford, Kristin I; Rasmussen, Morten; Baer, Lisa A et al. (2018) Paternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes 67:2530-2540

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