Abstract

The Animal Physiology Core provides services to characterize the physiological parameters of rodent models of diabetes, obesity and their associated complications. These services include measurements in the categories of energy homeostasis, energy expenditure during exercise, vascular studies, ischemic tissue studies and glucose homeostasis. Energy Homeostasis: Feeding/drinking behavior, body composition, oxygen consumption and activity monitoring (CLAMS and DEXA). Energy Expenditure During Exercise: Oxygen consumption during rodent treadmill running (TM). Vascular Studies: Blood pressure measurements by tail blood pressure cuffs and by telemetry (BP). Ischemic Tissue Studies: The OxyCycler (OC) is an in vivo system that controls the ambient oxygen concentration allowing investigation of the effects of hypoxia or hyperoxia on various organs and tissues. Glucose Homeostasis: Monitoring of blood glucose and insulin levels, intraperitoneal glucose tolerance tests (GTT), insulin tolerance tests (ITT). Available upon request by an investigator for teaching purposes only.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK036836-22
Application #
7622575
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
22
Fiscal Year
2008
Total Cost
$161,859
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Qi, Weier; Li, Qian; Gordin, Daniel et al. (2018) Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism. J Mol Med (Berl) 96:373-381
Adachi, Yusuke; De Sousa-Coelho, Ana Luisa; Harata, Ikue et al. (2018) l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab 17:61-70
Berkowitz, Robert I; Marcus, Marsha D; Anderson, Barbara J et al. (2018) Adherence to a lifestyle program for youth with type 2 diabetes and its association with treatment outcome in the TODAY clinical trial. Pediatr Diabetes 19:191-198
Musen, Gail; Tinsley, Liane J; Marcinkowski, Katrina A et al. (2018) Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications. Diabetes Care 41:1749-1756
Stanford, Kristin I; Lynes, Matthew D; Takahashi, Hirokazu et al. (2018) 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab 27:1357
Shah, Hetal S; Morieri, Mario Luca; Marcovina, Santica M et al. (2018) Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD. Diabetes Care 41:348-355
Mul, Joram D; Soto, Marion; Cahill, Michael E et al. (2018) Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ?FosB. Neuropsychopharmacology 43:1934-1942
Morieri, Mario Luca; Gao, He; Pigeyre, Marie et al. (2018) Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial. Diabetes Care 41:2404-2413
Rezanejad, Habib; Ouziel-Yahalom, Limor; Keyzer, Charlotte A et al. (2018) Heterogeneity of SOX9 and HNF1? in Pancreatic Ducts Is Dynamic. Stem Cell Reports 10:725-738
Katz, Michelle L; Guo, Zijing; Cheema, Alina et al. (2018) Management of Cardiovascular Disease Risk in Teens with Type 1 Diabetes: Perspectives of Teens With and Without Dyslipidemia and Parents. Pediatr Diabetes :

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