Abstract

The Animal Physiology Core provides services to characterize the physiological parameters of rodent models of diabetes, obesity and their associated complications. These services include measurements in the categories of energy homeostasis, energy expenditure during exercise, vascular studies, ischemic tissue studies and glucose homeostasis. Energy Homeostasis: Feeding/drinking behavior, body composition, oxygen consumption and activity monitoring (CLAMS and DEXA). Energy Expenditure During Exercise: Oxygen consumption during rodent treadmill running (TM). Vascular Studies: Blood pressure measurements by tail blood pressure cuffs and by telemetry (BP). Ischemic Tissue Studies: The OxyCycler (OC) is an in vivo system that controls the ambient oxygen concentration allowing investigation of the effects of hypoxia or hyperoxia on various organs and tissues. Glucose Homeostasis: Monitoring of blood glucose and insulin levels, intraperitoneal glucose tolerance tests (GTT), insulin tolerance tests (ITT). Available upon request by an investigator for teaching purposes only.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK036836-23
Application #
7809557
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
23
Fiscal Year
2009
Total Cost
$166,121
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Stanford, Kristin I; Lynes, Matthew D; Takahashi, Hirokazu et al. (2018) 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab 27:1111-1120.e3
Solheim, Marie H; Winnay, Jonathon N; Batista, Thiago M et al. (2018) Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes. Diabetes 67:1297-1309
Weir, Gordon C; Ehlers, Mario R; Harris, Kristina M et al. (2018) Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics. Pediatr Diabetes 19:945-954
McGill, Dayna E; Volkening, Lisa K; Butler, Deborah A et al. (2018) Baseline Psychosocial Characteristics Predict Frequency of Continuous Glucose Monitoring in Youth with Type 1 Diabetes. Diabetes Technol Ther 20:434-439
Adachi, Yusuke; De Sousa-Coelho, Ana Luisa; Harata, Ikue et al. (2018) l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab 17:61-70
Qi, Weier; Li, Qian; Gordin, Daniel et al. (2018) Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism. J Mol Med (Berl) 96:373-381
Musen, Gail; Tinsley, Liane J; Marcinkowski, Katrina A et al. (2018) Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications. Diabetes Care 41:1749-1756
Berkowitz, Robert I; Marcus, Marsha D; Anderson, Barbara J et al. (2018) Adherence to a lifestyle program for youth with type 2 diabetes and its association with treatment outcome in the TODAY clinical trial. Pediatr Diabetes 19:191-198
Shah, Hetal S; Morieri, Mario Luca; Marcovina, Santica M et al. (2018) Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD. Diabetes Care 41:348-355
Stanford, Kristin I; Lynes, Matthew D; Takahashi, Hirokazu et al. (2018) 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab 27:1357

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